Bronchial Challenge of Normal Subjects with the Endotoxin of Enterobacter Agglomerans Isolated from Cotton Dust

Endotoxin produced by a culture of Enterobacter agglomerans isolated from cotton dust was inhaled by 12 normal subjects. No significant airway constriction was obtained in doses equivalent to those experienced in a workshift in a dusty mill. There was a statistically significant difference between t...

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Bibliographic Details
Published in:British journal of industrial medicine 1986-05, Vol.43 (5), p.327-331
Main Authors: Jamison, J. P., Lowry, R. C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bronchoconstriction
Chemical and industrial products toxicology. Toxic occupational diseases
Cotton
Dosage
Endotoxins
Enterobacter
Enterobacter agglomerans
Fever
Inhalation
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Lungs
Medical sciences
Textiles
Toxicology
Vital capacity
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Summary:Endotoxin produced by a culture of Enterobacter agglomerans isolated from cotton dust was inhaled by 12 normal subjects. No significant airway constriction was obtained in doses equivalent to those experienced in a workshift in a dusty mill. There was a statistically significant difference between this result and the bronchoconstriction that had occurred after flax dust inhalation in the same subjects. It is suggested that Enterobacter agglomerans endotoxin is not the causative agent of the acute bronchoconstriction that follows inhalation of textile dust.
ISSN:0007-1072