Topical cholesterol treatment ameliorates hapten-evoked cutaneous hypersensitivity by sustaining expression of 11β-HSD1 in epidermis

Changes in the stratum corneum extracellular matrix impair epidermal barrier function and may cause dermatoses. The aim of this study was to examine the effect of exogenous cholesterol application on skin barrier function and cutaneous inflammation. Skin barrier‐disrupted or hapten‐stimulated mice w...

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Bibliographic Details
Published in:Experimental dermatology 2014-01, Vol.23 (1), p.68-70
Main Authors: Murota, Hiroyuki, Itoi, Saori, Terao, Mika, Matsui, Saki, Kawai, Hiromi, Satou, Yasunari, Suda, Kazuma, Katayama, Ichiro
Format: Article
Language:English
Subjects:
11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics
11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism
11β-hydroxysteroid dehydrogenase type 1
Administration, Topical
Animals
Body Water - metabolism
cholesterol
Cholesterol - administration & dosage
contact hypersensitivity
Dermatitis, Contact - enzymology
Dermatitis, Contact - immunology
Dermatitis, Contact - prevention & control
Epidermis - drug effects
Epidermis - enzymology
Epidermis - immunology
Gene Expression - drug effects
Haptens - administration & dosage
Hydrocortisone - metabolism
Mice
Mice, Inbred BALB C
Oxazolone - administration & dosage
Oxazolone - immunology
skin barrier
stratum corneum
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Summary:Changes in the stratum corneum extracellular matrix impair epidermal barrier function and may cause dermatoses. The aim of this study was to examine the effect of exogenous cholesterol application on skin barrier function and cutaneous inflammation. Skin barrier‐disrupted or hapten‐stimulated mice were treated with topical cholesterol. The effect of topical cholesterol application on an oxazolone (OXA)‐induced hypersensitivity reaction was evaluated. Topical application of cholesterol efficiently decreased transepidermal water loss in areas of barrier‐disrupted skin and ameliorated OXA‐induced cutaneous hypersensitivity. These favourable effects may have resulted from sustained expression of 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) in the cholesterol‐treated skin. As 11β‐HSD1 is known to produce active cortisol, topical cholesterol may attenuate contact hypersensitivity by normalizing secretion of hormonally active cortisol from the skin.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.12284