Genophenotypic Analysis of Angiotensinogen Gene M235T Polymorphism and Preeclampsia

We studied phenotypes of the circulating renin–angiotensin–aldosterone system and circadian BP during preeclampsia depending on polymorphism of angiotensinogen gene M235T. The TT genotype or T allele of angiotensinogen M235T gene polymorphism is associated with the risk of preeclampsia. Plasma renin...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013, Vol.154 (3), p.354-356
Main Authors: Radkov, O. V., Kalinkin, M. N., Zavarin, V. V.
Format: Article
Language:English
Subjects:
Aldosterone
Aldosterone - blood
Alleles
Angiotensin
Angiotensinogen - genetics
Biomedical and Life Sciences
Biomedicine
Blood Pressure
Cell Biology
Corticosteroids
Female
Gene Frequency
Genes
Genetic aspects
Genetic research
Genotype
Humans
Internal Medicine
Laboratory Medicine
Pathology
Phenotype
Polymorphism, Single Nucleotide
Pre-Eclampsia - genetics
Preeclampsia
Pregnancy
Pregnancy Trimester, Third
Renin - blood
Renin-Angiotensin System - genetics
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Summary:We studied phenotypes of the circulating renin–angiotensin–aldosterone system and circadian BP during preeclampsia depending on polymorphism of angiotensinogen gene M235T. The TT genotype or T allele of angiotensinogen M235T gene polymorphism is associated with the risk of preeclampsia. Plasma renin activity signifi cantly decreases under conditions of preeclampsia. The TT genotype of angiotensin M235T gene polymorphism is associated with highest renin activity and highest 24-h diastolic BP in comparison with MT and MM genotypes in patients with preeclampsia. Plasma aldosterone level is lower in patients with preeclampsia, but this is not related to angiotensinogen M235T gene polymorphism.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-1949-z