Chronic chlorpyrifos-induced oxidative changes in the testes and pituitary gland of Wistar rats: Ameliorative effects of vitamin C

Chlorpyrifos (CPF), a chlorinated organophosphate insecticide that is widely used in agriculture and public health, has been implicated in male reproductive toxicity. Apart from acetylcholinesterase inhibition, CPF has been shown to induce changes characteristic of oxidative stress. Therefore, the a...

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Bibliographic Details
Published in:Pesticide biochemistry and physiology 2012, Vol.102 (1), p.79-85
Main Authors: Shittu, M, Ayo, J.O, Ambali, S.F, Fatihu, M.Y, Onyeanusi, B.I, Kawu, M.U
Format: Article
Language:English
Subjects:
Acetylcholinesterase
adults
ascorbic acid
Biological and medical sciences
catalase
chlorination
Chlorpyrifos
chronic exposure
lethal dose 50
malondialdehyde
oral administration
Oxidative stress
Pituitary gland
public health
rats
reproductive toxicology
superoxide dismutase
Testes
Vitamin C
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Summary:Chlorpyrifos (CPF), a chlorinated organophosphate insecticide that is widely used in agriculture and public health, has been implicated in male reproductive toxicity. Apart from acetylcholinesterase inhibition, CPF has been shown to induce changes characteristic of oxidative stress. Therefore, the aim of the present study was to evaluate the effects of vitamin C on oxidative changes in the testes and pituitary gland of rats chronically exposed to CPF. Twenty adult male Wistar rats were divided into four groups of five animals each: Group I (S/oil) received soya oil (2ml/kg); Group II (VC) was administered with vitamin C (100mg/kg); Group III (CPF) was given CPF (10.6mg/kg; ∼1/8th LD50); Group IV (VC+CPF) was pretreated with vitamin C (100mg/kg) and then given CPF (10.6mg/kg), 30min later. The regimens were administered orally by gavage once daily for 15weeks. Thereafter, the rats were sacrificed and the testes and pituitary glands were evaluated for the concentration of malonaldehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT). The result shows that CPF increased MDA concentration and reduced activities of SOD and CAT, which were ameliorated by pretreatment with vitamin C.
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2011.10.014