Genetics of anti-EHV antibody responses in a horse population

Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analy...

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Bibliographic Details
Published in:Research in veterinary science 2013-08, Vol.95 (1), p.137-142
Main Authors: Rusek, J., Klumplerova, M., Molinkova, D., Sedlinska, M., Dusek, L., Muzik, J., Putnova, L., Vrtkova, I., Celer, V., Horin, P.
Format: Article
Language:English
Subjects:
Abortion
Age
Animals
Antibodies, Viral - blood
Antibody responsiveness
autumn
Chromosomes
colored varieties
Equine herpes virus
Female
Genes
genetic markers
Genetics
Genomes
Genotype
Herpes viruses
Herpesviridae Infections - genetics
Herpesviridae Infections - immunology
Herpesviridae Infections - veterinary
Herpesviridae Infections - virology
Herpesvirus 1, Equid - genetics
Herpesvirus 1, Equid - immunology
Horse Diseases - genetics
Horse Diseases - immunology
Horse Diseases - virology
Horses
immune response
Immune system
Immunity-related molecular markers
interleukin-4
Kladruby
Microsatellite Repeats
Microsatellites
Phenotype
Polymerase Chain Reaction - veterinary
Polymorphism, Single Nucleotide - genetics
single nucleotide polymorphism
spring
Statistical associations
Statistics, Nonparametric
Vaccines
Veterinary medicine
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Description
Summary:Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2013.03.011