Color-Code Agreement Among Stratus, Cirrus, and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis With and Without Prior Optic Neuritis

Purpose To evaluate the agreement of retinal nerve fiber layer (RNFL) color codes among Stratus, Cirrus, and Spectralis optical coherence tomography (OCT) in patients with relapsing-remitting multiple sclerosis. Design Prospective cohort study. Methods In 140 eyes from 70 patients having relapsing-r...

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Bibliographic Details
Published in:American journal of ophthalmology 2013-05, Vol.155 (5), p.890-897.e2
Main Authors: Rebolleda, Gema, González-López, Julio J, Muñoz-Negrete, Francisco J, Oblanca, Noelia, Costa-Frossard, Lucienne, Álvarez-Cermeño, José C
Format: Article
Language:English
Subjects:
Adult
Agreements
Codes
Color vision
Eyes & eyesight
Female
Follow-Up Studies
Humans
Male
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - diagnosis
Nerve Fibers - pathology
Ophthalmology
Optic nerve
Optic Neuritis - diagnosis
Optic Neuritis - etiology
Optics
Prospective Studies
Reproducibility of Results
Retinal Ganglion Cells - pathology
ROC Curve
Severity of Illness Index
Software
Standard deviation
Tomography, Optical Coherence - instrumentation
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Summary:Purpose To evaluate the agreement of retinal nerve fiber layer (RNFL) color codes among Stratus, Cirrus, and Spectralis optical coherence tomography (OCT) in patients with relapsing-remitting multiple sclerosis. Design Prospective cohort study. Methods In 140 eyes from 70 patients having relapsing-remitting multiple sclerosis from January 2011 to September 2011, peripapillary RNFL thickness was measured using the fast RNFL program by Stratus, the optic disc cube protocol by Cirrus, and the N-site axonal analysis by Spectralis. Results Overall, a moderate to good RNFL color code agreement was found (0.435-0.884), except for the nasal quadrant. The temporal quadrant was the most abnormal color coding by both Cirrus (64.7%) and Spectralis (61.7%) in both the optic neuritis (ON) and non-ON group and by Stratus (58.8%) in the ON group. Abnormal temporal RNFL color-code rate was significantly higher in ON eyes than non-ON eyes by Cirrus ( P < .001), Stratus ( P < .001), and Spectralis ( P  = .030). Overall, Cirrus significantly displayed abnormal findings while both Stratus and Spectralis displayed normal results for the inferior quadrant ( P  
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2012.11.025