Dissecting the Genetic Heterogeneity of Depression Through Age at Onset

Genome‐wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub‐types of depression with specific heritable components. This paper investigates the ro...

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Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2012-10, Vol.159B (7), p.859-868
Main Authors: Power, Robert A., Keers, Robert, Ng, Mandy Y., Butler, Amy W., Uher, Rudolf, Cohen-Woods, Sarah, Ising, Marcus, Craddock, Nick, Owen, Michael J., Korszun, Ania, Jones, Lisa, Jones, Ian, Gill, Michael, Rice, John P., Hauser, Joanna, Henigsberg, Neven, Maier, Wolfgang, Zobel, Astrid, Mors, Ole, Placentino, Anna S., Rietschel, Marcella, Souery, Daniel, Kozel, Dejan, Preisig, Martin, Lucae, Susanne, Binder, Elisabeth B., Aitchison, Katherine J., Tozzi, Federica, Muglia, Pierandrea, Breen, Gerome, Craig, Ian W., Farmer, Anne E., Müller-Myhsok, Bertram, McGuffin, Peter, Lewis, Cathryn M.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age
age at onset
Age of Onset
Biological and medical sciences
Case-Control Studies
Depression
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - genetics
Depressive Disorder, Major - psychology
Female
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetics
Genome-Wide Association Study
Genotype
heterogeneity
Humans
Male
Medical genetics
Medical sciences
Miscellaneous
Mood disorders
Phenotype
Polymorphism, Single Nucleotide
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Genome‐wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub‐types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome‐wide association data on 2,746 cases and 1,594 screened controls from the RADIANT studies, with replication performed in 1,471 cases and 1,403 controls from two Munich studies. Three methods were used to analyze AAO: First a time‐to‐event analysis with controls censored, secondly comparing controls to case‐subsets defined using AAO cut‐offs, and lastly analyzing AAO as a quantitative trait. In the time‐to‐event analysis three SNPs reached suggestive significance (P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.32093