Sensitivity of cognitive tests in four cognitive domains in discriminating MDD patients from healthy controls: a meta-analysis

Background: We performed a meta-analysis in order to determine which neuropsychological domains and tasks would be most sensitive for discriminating between patients with major depressive disorder (MDD) and healthy controls. Methods: Relevant articles were identified through a literature search of t...

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Published in:International psychogeriatrics 2013-09, Vol.25 (9), p.1543-1557
Main Authors: Lim, JaeHyoung, Oh, In Kyung, Han, Changsu, Huh, Yu Jeong, Jung, In-Kwa, Patkar, Ashwin A., Steffens, David C., Jang, Bo-Hyoung
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Age
Attention
Biological and medical sciences
Case-Control Studies
Cognition - physiology
Cognition Disorders - psychology
Cognitive ability
Depression
Depressive Disorder, Major - psychology
Executive Function - physiology
Geriatrics
Humans
Medical sciences
Memory
Mental depression
Meta-analysis
Mood disorders
Neuropsychological Tests - statistics & numerical data
Neuropsychology
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sensitivity and Specificity
Systematic review
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Summary:Background: We performed a meta-analysis in order to determine which neuropsychological domains and tasks would be most sensitive for discriminating between patients with major depressive disorder (MDD) and healthy controls. Methods: Relevant articles were identified through a literature search of the PubMed and Cochrane Library databases for the period between January 1997 and May 2011. A meta-analysis was conducted using the standardized means of individual cognitive tests in each domain. The heterogeneity was assessed, and subgroup analyses according to age and medication status were performed to explore the sources of heterogeneity. Results: A total of 22 trials involving 955 MDD patients and 7,664 healthy participants were selected for our meta-analysis. MDD patients showed significantly impaired results compared with healthy participants on the Digit Span and Continuous Performance Test in the attention domain; the Trail Making Test A (TMT-A) and the Digit Symbol Test in the processing speed domain; the Stroop Test, the Wisconsin Card Sorting Test, and Verbal Fluency in the executive function domain; and immediate verbal memory in the memory domain. The Finger Tapping Task, TMT-B, delayed verbal memory, and immediate and delayed visual memory failed to separate MDD patients from healthy controls. The results of subgroup analysis showed that performance of Verbal Fluency was significantly impaired in younger depressed patients (
ISSN:1041-6102
1741-203X
DOI:10.1017/S1041610213000689