KIR gene content does not contribute to susceptibility to Graves' disease

Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. To investigate the KIR gene profiles in relation to susceptibility to Graves'...

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Bibliographic Details
Published in:Iranian journal of immunology 2013-09, Vol.10 (3), p.150-157
Main Authors: Ashouri, Elham, Dabbaghmanesh, Mohammad Hossein, Hadaegh, Amirhossein, Rowhanirad, Soodeh, Bakhshayashkaram, Marizeh, Omrani, Gholamhossein Ranjbar
Format: Article
Language:English
Subjects:
Adult
Autoimmune diseases
Chemokine CCL1 - immunology
DNA Mutational Analysis
Female
Gene Expression Regulation
Genes
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Graves Disease - genetics
Graves Ophthalmopathy - genetics
Humans
Immune system
Immunology
Killer Cells, Natural - immunology
Male
Middle Aged
Polymorphism, Genetic
Receptors, KIR - genetics
Transcriptome
Young Adult
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Summary:Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. To investigate the KIR gene profiles in relation to susceptibility to Graves' disease in patients with ophthalmopathy. KIR genes profiles were analyzed in 90 patients presenting Graves' disease with ophthalmopathy representing upper eyelid retraction, swelling, redness, conjunctivitis, and bulging eyes and were compared with the KIR gene profiles of 112 healthy controls. The presence and absence of 11 variable KIR genes were characterized using a gene-specific PCR typing system. There was no significant difference in the distribution of KIR gene profiles between patients and controls. Our data show that none of the KIR genotypes contribute in susceptibility to Graves' disease; although the role of HLA ligand remains to be characterized.
ISSN:1735-1383
1735-367X