Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication

Gallic acid, a polyphenyl class natural product from gallnut and green tea, is known to be antioxidant, anti‐inflammatory and radical scavenger. In this study, we aimed to investigate the possible protective effects of gallic acid on paraoxonase and arylesterase activities in liver exposed to acute...

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Bibliographic Details
Published in:Cell biochemistry and function 2013-04, Vol.31 (3), p.208-213
Main Authors: Kartkaya, Kazim, Oğlakçı, Ayşegül, Şentürk, Hakan, Bayramoğlu, Gökhan, Canbek, Mediha, Kanbak, Güngör
Format: Article
Language:English
Subjects:
Alanine transaminase
Alanine Transaminase - blood
alcohol
Alcoholic Intoxication - enzymology
Alcoholic Intoxication - metabolism
Alcoholic Intoxication - pathology
Animals
Aryldialkylphosphatase - metabolism
arylesterase
Aspartate Aminotransferases - blood
Carboxylic Ester Hydrolases - metabolism
Ethanol - toxicity
Female
gallic acid
Gallic Acid - pharmacology
L-Lactate Dehydrogenase - blood
liver
Liver - drug effects
Liver - enzymology
Liver - pathology
paraoxonase
Protective Agents - pharmacology
Rats
Rats, Sprague-Dawley
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Summary:Gallic acid, a polyphenyl class natural product from gallnut and green tea, is known to be antioxidant, anti‐inflammatory and radical scavenger. In this study, we aimed to investigate the possible protective effects of gallic acid on paraoxonase and arylesterase activities in liver exposed to acute alcohol intoxication. Paraoxonase and arylesterase activities in liver tissue and serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histological investigations were also made. In our study, we observed a significant increase of serum alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, which are indicators of liver damage after acute ethanol consumption. Gallic acid therapy has significantly reduced the increase in these biomarkers, indicating a possible hepatoprotective effect of gallic acid. Ethanol consumption caused a significant decrease in liver paraoxonase activity (P 
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.2874