Loading…
Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability
Purposes Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. We analyzed the impact of MTHFR C677T polymorphism in colorectal cancer in a region of the Tenerife Island who...
Saved in:
| Published in: | International journal of colorectal disease 2013-09, Vol.28 (9), p.1187-1193 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03 |
| container_end_page | 1193 |
| container_issue | 9 |
| container_start_page | 1187 |
| container_title | International journal of colorectal disease |
| container_volume | 28 |
| creator | Delgado-Plasencia, Luciano Medina-Arana, Vicente Bravo-Gutiérrez, Alberto Pérez-Palma, Julián Álvarez-Argüelles, Hugo Salido-Ruiz, Eduardo Fernández-Peralta, Antonia M. González-Aguilera, Juan J. |
| description | Purposes
Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. We analyzed the impact of
MTHFR
C677T polymorphism in colorectal cancer in a region of the Tenerife Island whose population has a history of genetic isolation and a low genetic variability. This allows analyzing the effects of the polymorphism that are not due to interactions with different genetic variants.
Methods
Genomic DNA of 50 Spanish sporadic colorectal cancer (CRC) patients and 103 controls was analyzed by PCR/RFLP and sequencing.
Results
The T allele is more frequent in controls than in patients (
P
|
| doi_str_mv | 10.1007/s00384-013-1644-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492635608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492635608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVJabZpf0AvRZBLL271Zck6hiVpAimFsj0LWZ7NKsiWI8kJ---rZdMSCjkNwzzzzseL0CdKvlJC1LdMCO9EQyhvqBSikW_QigrOGsokO0ErQpVuqG67U_Q-53tSc6nEO3TKuGBMt3SFdjfjbF3BcYvLDvCPzfXVL7yWSm3wHMN-jGne-TziOGEXQ0zgig3Y2clBwn7CtmLzEmzxlXjyZYdDfMJ3MEHxDj_a5G3vgy_7D-jt1oYMH5_jGfp9dblZXze3P7_frC9uGydIW5peua3gwKTsXCfcQPjgmNaDpgp6TrUG17W011ZbUGKQemD1BV09TXRuAMLP0Jej7pziwwK5mNFnByHYCeKSDRWaSd5K0lX0_D_0Pi5pqttViikuhJIHih4pl2LOCbZmTn60aW8oMQcbzNEGU20wBxuMrD2fn5WXfoThX8ffv1eAHYFcS9MdpBejX1X9A35KkU4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1427344768</pqid></control><display><type>article</type><title>Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability</title><source>Springer Nature</source><creator>Delgado-Plasencia, Luciano ; Medina-Arana, Vicente ; Bravo-Gutiérrez, Alberto ; Pérez-Palma, Julián ; Álvarez-Argüelles, Hugo ; Salido-Ruiz, Eduardo ; Fernández-Peralta, Antonia M. ; González-Aguilera, Juan J.</creator><creatorcontrib>Delgado-Plasencia, Luciano ; Medina-Arana, Vicente ; Bravo-Gutiérrez, Alberto ; Pérez-Palma, Julián ; Álvarez-Argüelles, Hugo ; Salido-Ruiz, Eduardo ; Fernández-Peralta, Antonia M. ; González-Aguilera, Juan J.</creatorcontrib><description>Purposes
Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. We analyzed the impact of
MTHFR
C677T polymorphism in colorectal cancer in a region of the Tenerife Island whose population has a history of genetic isolation and a low genetic variability. This allows analyzing the effects of the polymorphism that are not due to interactions with different genetic variants.
Methods
Genomic DNA of 50 Spanish sporadic colorectal cancer (CRC) patients and 103 controls was analyzed by PCR/RFLP and sequencing.
Results
The T allele is more frequent in controls than in patients (
P
< 0.01). The variant (T) carriers displayed significant odds ratio values for the CT heterozygotes (
P
= 0.026) and even when grouping heterozygote (CT) and homozygotes (TT) (
P
= 0.015). Patients carriers of the variant T (CT y TT) show a higher survival rate after chemotherapy than the CC homozygotes (log rank;
P
= 0.001).
Conclusions
The
MTHRF
C677T variant has a protective effect on CRC development in a population with low allelic variability and an optimal intake of folic acid. Moreover, patients carrying the variant (T) show a better prognosis after 5-fluorouracil/folinic acid-based chemotherapy.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-013-1644-6</identifier><identifier>PMID: 23422951</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>5-Fluorouracil ; Amino Acid Substitution - genetics ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - enzymology ; Colorectal Neoplasms - genetics ; Female ; Gastroenterology ; Genetic Predisposition to Disease ; Hepatology ; Humans ; Internal Medicine ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Original Article ; Polymorphism, Single Nucleotide - genetics ; Proctology ; Risk Factors ; Surgery</subject><ispartof>International journal of colorectal disease, 2013-09, Vol.28 (9), p.1187-1193</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03</citedby><cites>FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23422951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delgado-Plasencia, Luciano</creatorcontrib><creatorcontrib>Medina-Arana, Vicente</creatorcontrib><creatorcontrib>Bravo-Gutiérrez, Alberto</creatorcontrib><creatorcontrib>Pérez-Palma, Julián</creatorcontrib><creatorcontrib>Álvarez-Argüelles, Hugo</creatorcontrib><creatorcontrib>Salido-Ruiz, Eduardo</creatorcontrib><creatorcontrib>Fernández-Peralta, Antonia M.</creatorcontrib><creatorcontrib>González-Aguilera, Juan J.</creatorcontrib><title>Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purposes
Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. We analyzed the impact of
MTHFR
C677T polymorphism in colorectal cancer in a region of the Tenerife Island whose population has a history of genetic isolation and a low genetic variability. This allows analyzing the effects of the polymorphism that are not due to interactions with different genetic variants.
Methods
Genomic DNA of 50 Spanish sporadic colorectal cancer (CRC) patients and 103 controls was analyzed by PCR/RFLP and sequencing.
Results
The T allele is more frequent in controls than in patients (
P
< 0.01). The variant (T) carriers displayed significant odds ratio values for the CT heterozygotes (
P
= 0.026) and even when grouping heterozygote (CT) and homozygotes (TT) (
P
= 0.015). Patients carriers of the variant T (CT y TT) show a higher survival rate after chemotherapy than the CC homozygotes (log rank;
P
= 0.001).
Conclusions
The
MTHRF
C677T variant has a protective effect on CRC development in a population with low allelic variability and an optimal intake of folic acid. Moreover, patients carrying the variant (T) show a better prognosis after 5-fluorouracil/folinic acid-based chemotherapy.</description><subject>5-Fluorouracil</subject><subject>Amino Acid Substitution - genetics</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Genetic Predisposition to Disease</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Proctology</subject><subject>Risk Factors</subject><subject>Surgery</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kU1r3DAQhkVJabZpf0AvRZBLL271Zck6hiVpAimFsj0LWZ7NKsiWI8kJ---rZdMSCjkNwzzzzseL0CdKvlJC1LdMCO9EQyhvqBSikW_QigrOGsokO0ErQpVuqG67U_Q-53tSc6nEO3TKuGBMt3SFdjfjbF3BcYvLDvCPzfXVL7yWSm3wHMN-jGne-TziOGEXQ0zgig3Y2clBwn7CtmLzEmzxlXjyZYdDfMJ3MEHxDj_a5G3vgy_7D-jt1oYMH5_jGfp9dblZXze3P7_frC9uGydIW5peua3gwKTsXCfcQPjgmNaDpgp6TrUG17W011ZbUGKQemD1BV09TXRuAMLP0Jej7pziwwK5mNFnByHYCeKSDRWaSd5K0lX0_D_0Pi5pqttViikuhJIHih4pl2LOCbZmTn60aW8oMQcbzNEGU20wBxuMrD2fn5WXfoThX8ffv1eAHYFcS9MdpBejX1X9A35KkU4</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Delgado-Plasencia, Luciano</creator><creator>Medina-Arana, Vicente</creator><creator>Bravo-Gutiérrez, Alberto</creator><creator>Pérez-Palma, Julián</creator><creator>Álvarez-Argüelles, Hugo</creator><creator>Salido-Ruiz, Eduardo</creator><creator>Fernández-Peralta, Antonia M.</creator><creator>González-Aguilera, Juan J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130901</creationdate><title>Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability</title><author>Delgado-Plasencia, Luciano ; Medina-Arana, Vicente ; Bravo-Gutiérrez, Alberto ; Pérez-Palma, Julián ; Álvarez-Argüelles, Hugo ; Salido-Ruiz, Eduardo ; Fernández-Peralta, Antonia M. ; González-Aguilera, Juan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>5-Fluorouracil</topic><topic>Amino Acid Substitution - genetics</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - enzymology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Genetic Predisposition to Disease</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Proctology</topic><topic>Risk Factors</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delgado-Plasencia, Luciano</creatorcontrib><creatorcontrib>Medina-Arana, Vicente</creatorcontrib><creatorcontrib>Bravo-Gutiérrez, Alberto</creatorcontrib><creatorcontrib>Pérez-Palma, Julián</creatorcontrib><creatorcontrib>Álvarez-Argüelles, Hugo</creatorcontrib><creatorcontrib>Salido-Ruiz, Eduardo</creatorcontrib><creatorcontrib>Fernández-Peralta, Antonia M.</creatorcontrib><creatorcontrib>González-Aguilera, Juan J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delgado-Plasencia, Luciano</au><au>Medina-Arana, Vicente</au><au>Bravo-Gutiérrez, Alberto</au><au>Pérez-Palma, Julián</au><au>Álvarez-Argüelles, Hugo</au><au>Salido-Ruiz, Eduardo</au><au>Fernández-Peralta, Antonia M.</au><au>González-Aguilera, Juan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>28</volume><issue>9</issue><spage>1187</spage><epage>1193</epage><pages>1187-1193</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Purposes
Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. We analyzed the impact of
MTHFR
C677T polymorphism in colorectal cancer in a region of the Tenerife Island whose population has a history of genetic isolation and a low genetic variability. This allows analyzing the effects of the polymorphism that are not due to interactions with different genetic variants.
Methods
Genomic DNA of 50 Spanish sporadic colorectal cancer (CRC) patients and 103 controls was analyzed by PCR/RFLP and sequencing.
Results
The T allele is more frequent in controls than in patients (
P
< 0.01). The variant (T) carriers displayed significant odds ratio values for the CT heterozygotes (
P
= 0.026) and even when grouping heterozygote (CT) and homozygotes (TT) (
P
= 0.015). Patients carriers of the variant T (CT y TT) show a higher survival rate after chemotherapy than the CC homozygotes (log rank;
P
= 0.001).
Conclusions
The
MTHRF
C677T variant has a protective effect on CRC development in a population with low allelic variability and an optimal intake of folic acid. Moreover, patients carrying the variant (T) show a better prognosis after 5-fluorouracil/folinic acid-based chemotherapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23422951</pmid><doi>10.1007/s00384-013-1644-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2013-09, Vol.28 (9), p.1187-1193 |
| issn | 0179-1958 1432-1262 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1492635608 |
| source | Springer Nature |
| subjects | 5-Fluorouracil Amino Acid Substitution - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Female Gastroenterology Genetic Predisposition to Disease Hepatology Humans Internal Medicine Kaplan-Meier Estimate Male Medicine Medicine & Public Health Methylenetetrahydrofolate Reductase (NADPH2) - genetics Original Article Polymorphism, Single Nucleotide - genetics Proctology Risk Factors Surgery |
| title | Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T13%3A59%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20the%20MTHFR%20C677T%20polymorphism%20on%20colorectal%20cancer%20in%20a%20population%20with%20low%20genetic%20variability&rft.jtitle=International%20journal%20of%20colorectal%20disease&rft.au=Delgado-Plasencia,%20Luciano&rft.date=2013-09-01&rft.volume=28&rft.issue=9&rft.spage=1187&rft.epage=1193&rft.pages=1187-1193&rft.issn=0179-1958&rft.eissn=1432-1262&rft_id=info:doi/10.1007/s00384-013-1644-6&rft_dat=%3Cproquest_cross%3E1492635608%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-b7cf43e2668c84cd03dc299d917eb3199ec851b9a9ae74d69d2384800148cde03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1427344768&rft_id=info:pmid/23422951&rfr_iscdi=true |