In vivo evaluation of brain damage in the course of systemic lupus erythematosus using magnetic resonance spectroscopy, perfusion-weighted and diffusion-tensor imaging

Twenty-two neuropsychiatric (NPSLE) and 13 systemic lupus erythematosus (SLE) patients with a normal appearing brain on plain magnetic resonance (MR) as well as 20 age-matched healthy controls underwent MR spectroscopy (MRS), perfusion-weighted (PWI) and diffusion-tensor imaging (DTI). In MRS NAA/Cr...

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Bibliographic Details
Published in:Lupus 2014-01, Vol.23 (1), p.10-19
Main Authors: Zimny, A, Szmyrka-Kaczmarek, M, Szewczyk, P, Bladowska, J, Pokryszko-Dragan, A, Gruszka, E, Wiland, P, Sasiadek, M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood
Brain - pathology
Brain damage
Case-Control Studies
Diffusion Tensor Imaging - methods
Humans
Lupus
Lupus Erythematosus, Systemic - pathology
Magnetic Resonance Angiography - methods
Magnetic resonance imaging
Magnetic Resonance Spectroscopy - methods
Male
Medical imaging
Metabolism
Metabolites
Middle Aged
Nervous system
Neuroimaging
Rheumatology
Spectrum analysis
Tomography
Young Adult
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Summary:Twenty-two neuropsychiatric (NPSLE) and 13 systemic lupus erythematosus (SLE) patients with a normal appearing brain on plain magnetic resonance (MR) as well as 20 age-matched healthy controls underwent MR spectroscopy (MRS), perfusion-weighted (PWI) and diffusion-tensor imaging (DTI). In MRS NAA/Cr, Cho/Cr and mI/Cr ratios were calculated from the posterior cingulate cortex and left parietal white matter. In PWI, values of cerebral blood volume (CBV) were assessed from 14 regions, including gray and white matter. In DTI fractional anisotropy (FA) values were obtained from 14 white matter tracts including projection, commissural and association fibers. All MR measurements were correlated with clinical data. SLE and NPSLE patients showed significantly (p 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203313511556