Effect of a mixture of bovine milk oligosaccharides, Lactobacillus rhamnosus NCC4007 and long-chain polyunsaturated fatty acids on catch-up growth of intra-uterine growth-restricted rats

• Published in: Acta Physiologica 2014-01, Vol.210 (1), p.161-173
• Main Authors: Castañeda-Gutiérrez, E., Moser, M., García-Ródenas, C., Raymond, F., Mansourian, R., Rubio-Aliaga, I., Viguet-Carrin, S., Metairon, S., Ammon-Zufferey, C., Avanti-Nigro, O., Macé, K., Silva-Zolezzi, I.
• Format: Article
• Language: English
• Subjects: Adiposity - drug effects; Animals; Body Size; early growth; Fatty Acids, Unsaturated - therapeutic use; Female; Fetal Growth Retardation - physiopathology; Fetal Growth Retardation - therapy; intrauterine growth restriction; Lactobacillus rhamnosus; long-chain polyunsaturated fatty acids; Male; Milk - chemistry; prebiotic; probiotic; Rats; Rats, Sprague-Dawley; Weight Gain - drug effects
• ISSN: 1748-1708; 1748-1716
• DOI: 10.1111/apha.12145

Aim To investigate the effect of a nutritional mixture (bovine milk oligosaccharides, Lactobacillus rhamnosus NCC4007, arachidonic and docosahexaenoic acid) on growth of intrauterine growth‐restricted (IUGR) rats. Methods IUGR was induced by maternal food restriction. The offspring (males and females) were assigned to: REF (non‐IUGR, no mixture), IUGRc (IUGR, no mixture), or IUGRmx (IUGR, mixture). The mixture was given from day 7 to day 58, when tissues and plasma from half of the animals were collected for hormones, metabolites and microarray analysis. The rest received a high‐fat diet (HFD) until day 100. Glucose tolerance was measured at 56 and 98 days, and body fat content at 21, 52 and 97 days. Results IUGRmx had the greatest growth during lactation, but from day 22 to day 54, both IUGR groups gained less body weight than the REF (P