Tumor response after low-dose preoperative radiotherapy combined with chemotherapy for squamous cell esophageal carcinoma

• Published in: Anticancer research 2013-03, Vol.33 (3), p.1157-1161
• Main Authors: Kobayashi, Noriko, Nakayama, Hidetsugu, Osaka, Yoshiaki, Tachibana, Shingo, Nogi, Sachika, Tajima, Yu, Okubo, Mitsuru, Mikami, Ryuji, Kanesaka, Naoto, Sugahara, Shinji, Hoshino, Sumito, Tsuchida, Akihiko, Tokuuye, Koichi
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Carcinoma, Squamous Cell - therapy; Chemoradiotherapy - adverse effects; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Neoplasms - therapy; Female; Humans; Male; Middle Aged; Neoplasm Staging; Radiation Dosage
• ISSN: 0250-7005; 1791-7530

Patients with T3 or more squamous cell esophageal cancer underwent low-dose preoperative radiotherapy with chemotherapy, to reduce local recurrence, followed by surgery. The aim was to ascertain tumor response and assess prognostic factors. Between May 2002 and June 2011, 37 consecutive patients with esophageal cancer underwent chemoradiotherapy followed by surgery. The numbers of patients in clinical stages IIA/IIIA/IIIB/IIIC were 2/24/7/4, respectively. All were given a dose of 30 Gy in 15 fractions, with concurrent chemotherapy using cisplatin and fluorouracil. Curative surgery was performed a median of 1.2 months after completion of chemoradiotherapy. Based on the findings from surgery, 26 patients (70%) achieved a stage reduction and six patients (16%) had a complete pathological response. The numbers of patients undergoing resections microscopically complete, with microscopically positive margins, and macroscopically positive margins were 33, 3, and 1, respectively. During a median follow-up period of 22.5 months, the two-year progression-free survival and overall survival were 62.1% [95% confidence interval (CI)=45.8 to 78.4%] and 71.9% [95% CI=55.1 to 88.7%], respectively. Statistically significant prognostic factors for overall survival were age [hazard ratio=6.6; 95% CI=1.1 to 38; p=0.04] and pathological T factor [hazard ratio=10.2; 95% CI=1.4 to 77; p=0.02]. No patients died as a result of surgery. Seventy percent of patients with esophageal cancer who received radiotherapy dose of 30 Gy in 15 fractions combined with chemotherapy achieved a stage reduction with low toxicity.