HLA-A, HLA-B, HLA-DRB1 allele and haplotype frequencies in 6384 umbilical cord blood units and transplantation matching and engraftment statistics in the Zhejiang cord blood bank of China

Summary Umbilical cord blood (UCB) is a widely accepted source of progenitor cells, and now, many cord blood banks were established. Here, we analysed the HLA‐A, HLA‐B and HLA‐DRB1 allele and haplotype frequencies, HLA matching possibilities for searching potential donors and outcome of UCB transpla...

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Bibliographic Details
Published in:International journal of immunogenetics 2014-02, Vol.41 (1), p.13-19
Main Authors: Wang, F., He, J., Chen, S., Qin, F., Dai, B., Zhang, W., Zhu, FM, Lv, HJ
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Blood Banks
Child
Child, Preschool
China
Cord Blood Stem Cell Transplantation
Fetal Blood
Gene Frequency
Genetics, Population
Graft Survival
Haplotypes
Histocompatibility Testing
HLA-A Antigens - genetics
HLA-A Antigens - immunology
HLA-B Antigens - genetics
HLA-B Antigens - immunology
HLA-DRB1 Chains - genetics
HLA-DRB1 Chains - immunology
Humans
Infant
Linkage Disequilibrium
Young Adult
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Summary:Summary Umbilical cord blood (UCB) is a widely accepted source of progenitor cells, and now, many cord blood banks were established. Here, we analysed the HLA‐A, HLA‐B and HLA‐DRB1 allele and haplotype frequencies, HLA matching possibilities for searching potential donors and outcome of UCB transplantations in Zhejiang cord blood bank of China. A total of 6384 UCB units were characterized for 17 HLA‐A, 30 HLA‐B and 13 HLA‐DRB1 alleles at the first field resolution level. Additionally, B*14, B*15 and B*40 were typed to the second field level. A total of 1372 distinct A‐B‐DRB1 haplotypes were identified. The frequencies of 7 haplotypes were more than 1%, and 439 haplotypes were
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12064