An amino-terminal fragment of hemokinin-1 has an inhibitory effect on pruritic processing in rats

Highlights • HK-1 (6–11) and SP (6–11) elicited excitatory effects, while HK-1 (1–5) and SP (1–5) attenuated the effect of HK-1 and SP. • HK-1 (1–5) and SP (1–5) inhibited formalin-induced nociceptive behavior. • HK-1 (1–5) attenuated serotonin- and histamine-induced pruritic behavior. • HK-1 (1–5)...

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Bibliographic Details
Published in:Neuroscience 2014-02, Vol.259, p.172-183
Main Authors: Naono-Nakayama, R, Ikeda, T, Matsushima, O, Sameshima, H, Takamiya, K, Funahashi, H, Nishimori, T
Format: Article
Language:English
Subjects:
amino-terminal fragment
Analysis of Variance
Animals
Biological and medical sciences
Disease Models, Animal
Drug Administration Routes
Fundamental and applied biological sciences. Psychology
hemokinin-1
Injections, Spinal
Male
Neurology
nociception
Pain Measurement
Peptide Fragments - toxicity
Proto-Oncogene Proteins c-fos - metabolism
pruritus
Pruritus - chemically induced
Rats
Rats, Sprague-Dawley
scratching
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
spinal cord
Substance P - adverse effects
Tachykinins - adverse effects
Tachykinins - chemistry
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Highlights • HK-1 (6–11) and SP (6–11) elicited excitatory effects, while HK-1 (1–5) and SP (1–5) attenuated the effect of HK-1 and SP. • HK-1 (1–5) and SP (1–5) inhibited formalin-induced nociceptive behavior. • HK-1 (1–5) attenuated serotonin- and histamine-induced pruritic behavior. • HK-1 (1–5) suppresses pruritic and nociceptive processing, while SP (1–5) inhibits nociceptive processing.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.10.070