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AMPK activation regulates neuronal structure in developing hippocampal neurons

Highlights • AMPK subunits upregulated during neuronal development. • Knockout of either AMPK catalytic subunit does not affect basal axon or dendrite growth. • Activation of AMPK during development impairs axogenesis and dendrite growth and arborization. • Activation of AMPK inhibits the positive r...

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Bibliographic Details
Published in:Neuroscience 2014-02, Vol.259, p.13-24
Main Authors: Ramamurthy, S, Chang, E, Cao, Y, Zhu, J, Ronnett, G.V
Format: Article
Language:English
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Summary:Highlights • AMPK subunits upregulated during neuronal development. • Knockout of either AMPK catalytic subunit does not affect basal axon or dendrite growth. • Activation of AMPK during development impairs axogenesis and dendrite growth and arborization. • Activation of AMPK inhibits the positive regulators of dendritic growth Akt and mTOR.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.11.048