Familial history of non-medullary thyroid cancer is an independent prognostic factor for tumor recurrence in younger patients with conventional papillary thyroid carcinoma

Background It is not clear whether familial non‐medullary thyroid cancer (FNMTC) is more aggressive and has a poorer prognosis, than sporadic carcinoma. Therefore, the optimal clinical approach for FNMTC is yet to be established. In this study, we investigated the biological behavior and prognosis o...

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Bibliographic Details
Published in:Journal of surgical oncology 2014-02, Vol.109 (2), p.168-173
Main Authors: Lee, Yu-Mi, Yoon, Jong Ho, Yi, Onvox, Sung, Tae-Yon, Chung, Ki-Wook, Kim, Won Bae, Hong, Suck Joon
Format: Article
Language:English
Subjects:
Age Factors
bilaterality
Carcinoma, Papillary - genetics
Carcinoma, Papillary - mortality
Carcinoma, Papillary - pathology
Carcinoma, Papillary - surgery
Disease-Free Survival
familial non-medullary thyroid cancer
Female
Follow-Up Studies
Humans
Lymph Nodes - pathology
Male
Middle Aged
multi-centricity
Multivariate Analysis
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Prognosis
recurrence
Retrospective Studies
Risk Factors
Sex Factors
Thyroid Neoplasms - genetics
Thyroid Neoplasms - mortality
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
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Summary:Background It is not clear whether familial non‐medullary thyroid cancer (FNMTC) is more aggressive and has a poorer prognosis, than sporadic carcinoma. Therefore, the optimal clinical approach for FNMTC is yet to be established. In this study, we investigated the biological behavior and prognosis of FNMTC compared with its sporadic counterpart. Methods Between 1996 and 2004, 1,262 patients underwent a total thyroidectomy for conventional PTC at Asan Medical Center and 113 (9.0%) were diagnosed with FNMTC. We compared the clinico‐pathologic characteristics, treatment modalities, and prognosis between familial and sporadic NMTC. Results FNMTC was significantly more multi‐centric than sporadic. We also found that family history itself was an independent risk factor for recurrence. Moreover, disease‐free survival in the familial group was significantly shorter than in the sporadic group in the subgroups in which age was
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.23447