A near-infrared colorimetric fluorescent chemodosimeter for the detection of glutathione in living cells

A novel near-infrared (NIR) and colorimetric fluorescent molecular probe based on a dicyanomethylene-4H-pyran chromophore for the selective detection of glutathione in living cells has been developed. The fluorescence OFF-ON switch is triggered by cleavage of the 2,4-dinitrobenzensulfonyl (DNBS) uni...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-02, Vol.50 (14), p.1751-1753
Main Authors: Li, Meng, Wu, Xumeng, Wang, Yao, Li, Yongsheng, Zhu, Weihong, James, Tony D
Format: Article
Language:English
Subjects:
Cell Survival
Chemistry Techniques, Analytical - instrumentation
Colorimetry
Glutathione - analysis
Glutathione - chemistry
HeLa Cells
Humans
Infrared Rays
Spectrometry, Fluorescence
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Summary:A novel near-infrared (NIR) and colorimetric fluorescent molecular probe based on a dicyanomethylene-4H-pyran chromophore for the selective detection of glutathione in living cells has been developed. The fluorescence OFF-ON switch is triggered by cleavage of the 2,4-dinitrobenzensulfonyl (DNBS) unit by the interaction with GSH.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc48128j