Monocyte-derived dendritic cells: targets as potent antigen-presenting cells for the design of vaccines against infectious diseases

Summary Monocytes play important roles in the inflammatory response, which is essential for the innate response to pathogens. Monocytes are able to differentiate to dendritic cells (DCs) under inflammatory situations. In recent decades, the heterogeneity of monocytes and their different traffic path...

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Bibliographic Details
Published in:International journal of infectious diseases 2014-02, Vol.19, p.1-5
Main Authors: Qu, Chunfeng, Brinck-Jensen, Nanna-Sophie, Zang, Mengya, Chen, Kun
Format: Article
Language:English
Subjects:
Animals
Antigen-Presenting Cells - immunology
Cell Differentiation
Chronic Disease
Communicable Disease Control
Communicable Diseases - immunology
Dendritic Cells - immunology
Humans
Infectious Disease
Infectious diseases
Inflammation - immunology
Mice
Monocyte-derived dendritic cells
Monocytes
Monocytes - immunology
Phenotype
Pulmonary/Respiratory
Vaccine design
Vaccines
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Summary:Summary Monocytes play important roles in the inflammatory response, which is essential for the innate response to pathogens. Monocytes are able to differentiate to dendritic cells (DCs) under inflammatory situations. In recent decades, the heterogeneity of monocytes and their different traffic pathways have been identified in both human and murine systems. Different monocyte subsets show distinct inflammatory cytokine profiles and differentiation potential under steady-state and inflammatory situations. We discuss the biology of monocytes, their relationship with DCs, and the potential of monocyte-derived dendritic cells (moDCs) in the design of vaccines against certain chronic infectious diseases.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2013.09.023