Oxidative Stress in Alopecia Areata: A Case–Control Study

Background Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, including atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris, and lichen planus. In alopecia areata (AA), there is increased production of ROS from perifollicular...

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Bibliographic Details
Published in:American journal of clinical dermatology 2014-02, Vol.15 (1), p.57-64
Main Authors: Bakry, Ola Ahmed, Elshazly, Rania Mohamed Azmy, Shoeib, Mohamed Abdel Moneim, Gooda, Amira
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alopecia Areata - physiopathology
Antioxidants - metabolism
Case-Control Studies
Child
Dermatology
Female
Humans
Inflammation - pathology
Lipid Peroxidation
Male
Malondialdehyde - metabolism
Medicine
Medicine & Public Health
Middle Aged
Original Research Article
Oxidants - metabolism
Oxidative Stress
Pharmacology/Toxicology
Pharmacotherapy
Young Adult
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Summary:Background Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, including atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris, and lichen planus. In alopecia areata (AA), there is increased production of ROS from perifollicular inflammatory cells. Objective The aim of this study was to determine the oxidative stress index (OSI) and lipid peroxidation by studying serum total oxidant capacity (TOC), total antioxidant capacity (TAC), and malondialdehyde (MDA) values in AA patients. Methods The study included 35 AA patients and a control group consisting of 30 age- and sex-matched healthy volunteers. The serum TOC, TAC, and MDA values were measured, and the OSIs were calculated and compared in both groups. Results The mean serum TOC ( p  
ISSN:1175-0561
1179-1888
DOI:10.1007/s40257-013-0036-6