Loading…
Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic: prevalence and impact on reproductive health
Summary Objective Iodine deficiency is associated with thyroid dysfunction and adverse pregnancy outcomes. The aim of our study was to investigate the status of iodine saturation in women after spontaneous abortion (SpA) residing in an iodine‐sufficient area and to evaluate their subsequent reproduc...
Saved in:
Published in: | Clinical endocrinology (Oxford) 2014-03, Vol.80 (3), p.452-458 |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Summary
Objective
Iodine deficiency is associated with thyroid dysfunction and adverse pregnancy outcomes. The aim of our study was to investigate the status of iodine saturation in women after spontaneous abortion (SpA) residing in an iodine‐sufficient area and to evaluate their subsequent reproductive health.
Design
Nonrandomized prospective follow‐up study.
Patients and methods
We compared urinary iodine concentration (UIC) in 171 women 2–8 weeks (median 4) after an early SpA with age‐matched controls. Women with known thyroid diseases were excluded. We also analysed a relationship of UIC to serum thyroid‐stimulating hormone, free thyroxine, antibodies against thyroid peroxidase and thyroid ultrasound. Afterwards, we followed the women for a median of 38 months (range 12–47). We used a multivariate regression analysis to assess the influence of iodine status and other thyroid biochemical and ultrasound parameters on their subsequent reproductive health.
Results
Women after SpA were almost twice as likely to suffer from mild iodine deficiency and had lower median UIC as compared to age‐matched controls [rate 105/181 (58·0%) vs 57/181 (31·5%), P |
---|---|
ISSN: | 0300-0664 1365-2265 |
DOI: | 10.1111/cen.12298 |