Characteristic of bacteriocines and their application

Bacteriocines are small peptides with anti-bacterial properties. They are produced both by Gram-positive and Gram-negative bacteria. Until now, a few hundred bacteriocines were described. Classification of bacteriocines undergoes continuous alterations, as new developments regarding their structure,...

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Bibliographic Details
Published in:Polish journal of microbiology 2013, Vol.62 (3), p.223-235
Main Authors: Karpiński, Tomasz M, Szkaradkiewicz, Anna K
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - genetics
Bacteria - metabolism
Bacteriocins - chemistry
Bacteriocins - classification
Bacteriocins - pharmacology
Humans
Protein Structure, Secondary
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Summary:Bacteriocines are small peptides with anti-bacterial properties. They are produced both by Gram-positive and Gram-negative bacteria. Until now, a few hundred bacteriocines were described. Classification of bacteriocines undergoes continuous alterations, as new developments regarding their structure, amino acid sequence and recognised mechanism of their action are available. Some of bacteriocins (lantibiotics) contain atypical amino acids, such as lantionine (Lan), methyllantionine (MeLan), dehydroalanine (Dha), dehydrobutyrine (Dhb), or D-alanine (D-Ala). The best recognized bacteriocines are produced by lactic acid bacteria, including nisine produced by strains of Lactococcus lactis. These bacteriocines have been recognized to be fully safe for humans. At present, nisine is used in food industry, as a preserving agent. Other lactic acid bacteria bacteriocines and probiotic preparations provide an alternative for antibiotics, and are used in food and in animal feed.
ISSN:1733-1331
2544-4646
DOI:10.33073/pjm-2013-030