Myocardin and smooth muscle differentiation

•MYOCD induces SM gene expression and inhibits cell proliferation.•Activity of MYOCD is regulated at transcriptional and post-translational levels.•SM contractility can be regulated by MYOCD. Myocardin (MYOCD), a co-transcriptional activator of serum response factor (SRF), stimulates the expression...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2014-02, Vol.543, p.48-56
Main Author: Zheng, Xi-Long
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Gene Expression Regulation
Humans
Models, Biological
Muscle Contraction
Muscle, Smooth - cytology
Muscle, Smooth - metabolism
Muscle, Smooth - physiology
Myocardin
Nuclear Proteins - chemistry
Nuclear Proteins - deficiency
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Smooth muscle cell proliferation
Smooth muscle differentiation
Trans-Activators - chemistry
Trans-Activators - deficiency
Trans-Activators - genetics
Trans-Activators - metabolism
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Summary:•MYOCD induces SM gene expression and inhibits cell proliferation.•Activity of MYOCD is regulated at transcriptional and post-translational levels.•SM contractility can be regulated by MYOCD. Myocardin (MYOCD), a co-transcriptional activator of serum response factor (SRF), stimulates the expression of smooth muscle (SM) genes and inhibits the cell cycle. In addition to its roles in the development, MYOCD may be critically involved in the pathogenesis of proliferative vascular diseases. This review mainly focuses on how MYOCD activity is regulated and how it inhibits cell proliferation.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2013.12.015