Radiation therapy for pleomorphic adenoma of the parotid

• Published in: Cancer radiothérapie 2014-01, Vol.18 (1), p.68-76
• Main Authors: Jardel, P, Fakhry, N, Makeieff, M, Ferrie, J-C, Milin, S, Righini, C, Lacout, A, Costes, V, Malard, O, Marcy, P-Y, Guevara, N, Odin, G, Bensadoun, R-J, Thariat, J
• Format: Article
• Language: fre
• Subjects: Adenoma, Pleomorphic - diagnosis; Adenoma, Pleomorphic - epidemiology; Adenoma, Pleomorphic - radiotherapy; Adenoma, Pleomorphic - surgery; Age Factors; Facial Nerve Injuries - prevention & control; Humans; Neoplasm Recurrence, Local - prevention & control; Neoplasms, Radiation-Induced - prevention & control; Organ Sparing Treatments; Parotid Neoplasms - diagnosis; Parotid Neoplasms - epidemiology; Parotid Neoplasms - radiotherapy; Parotid Neoplasms - surgery; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Prognosis; Radiation Injuries - prevention & control; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Adjuvant
• ISSN: 1769-6658
• DOI: 10.1016/j.canrad.2013.09.007

Parotid pleomorphic adenoma is the most frequent tumor of salivary glands. The prognosis depends on the recurrences because they could lead to iatrogenic events (facial paralysis). Moreover the risk of malignant transformation increases with the number of local relapses. This article aims at reviewing histological and radiological criteria and the surgical techniques. To improve local control, adjuvant irradiation (in first intention or after recurrence) may be useful but is still controversial for benign tumors in young patients with a risk of radio-induced cancer. We listed studies in which adjuvant radiotherapy was used so as to define its place in the treatment strategy. Prognostic factors were found by some authors. Other studies have to be done before strong evidence-based recommendations are issued.