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Sugammadex hypersensitivity-a case of anaphylaxis
We describe a case of a patient undergoing open abdominal aneurysm surgery who developed a severe, life-threatening allergic reaction immediately after administration of sugammadex. The manifestation was purely a cardiovascular collapse. The mainstay of treatment was administration of high-dose adre...
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Published in: | Anaesthesia and intensive care 2014-01, Vol.42 (1), p.89-92 |
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description | We describe a case of a patient undergoing open abdominal aneurysm surgery who developed a severe, life-threatening allergic reaction immediately after administration of sugammadex. The manifestation was purely a cardiovascular collapse. The mainstay of treatment was administration of high-dose adrenaline and fluid resuscitation. The diagnosis of anaphylaxis was supported by a positive serum mast cell tryptase (93 µg/l) at one hour post-event. Sugammadex was confirmed as the cause of the anaphylaxis by a positive intradermal allergy test (25 mm diameter response to 1:100 dilution), with a normal saline control and a negative response to the other drugs used during the event. This case report is a reminder that the use of sugammadex is associated with rare but serious risks. |
doi_str_mv | 10.1177/0310057x1404200115 |
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subjects | Anaphylaxis - chemically induced Anaphylaxis - therapy Aortic Aneurysm, Abdominal - surgery Drug Hypersensitivity - etiology gamma-Cyclodextrins - adverse effects Humans Male Middle Aged Neuromuscular Blockade Sugammadex |
title | Sugammadex hypersensitivity-a case of anaphylaxis |
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