Incidence and Epidemiology of Intussusception among Infants in Ho Chi Minh City, Vietnam

Objective To evaluate rates of intussusception hospitalization among infants in Vietnam before the introduction of rotavirus vaccine. Study design Between 2009 and 2011, we identified intussusception hospitalizations among infants using the International Statistical Classification of Diseases and Re...

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Published in:The Journal of pediatrics 2014-02, Vol.164 (2), p.366-371
Main Authors: Van Trang, Nguyen, PhD, Le Nguyen, Nhan Thanh, MD, Dao, Hieu Trung, MD, Ho, Viet Lu, MD, Tran, Dieu Thi, MD, Loewen, Jonathan, MD, Jiang, James, Jiang, Baoming, PhD, Parashar, Umesh, MBBS, MPH, Dang, Anh Duc, PhD, Patel, Manish M., MD, MSc
Format: Article
Language:English
Subjects:
Child, Preschool
Female
Hospitalization - statistics & numerical data
Humans
Incidence
Infant
Intussusception - diagnostic imaging
Intussusception - epidemiology
Male
Pediatrics
Retrospective Studies
Ultrasonography
Urban Population
Vietnam - epidemiology
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Summary:Objective To evaluate rates of intussusception hospitalization among infants in Vietnam before the introduction of rotavirus vaccine. Study design Between 2009 and 2011, we identified intussusception hospitalizations among infants using the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Clinical Modification code K56.1 at 2 large pediatric hospitals in Ho Chi Minh City, Vietnam that treat most of the intussusception cases in the city. We reviewed all medical records to confirm a Brighton level 1 case definition for intussusception. Results We identified a total of 869 intussusception cases in Ho Chi Minh City during the 3-year study period, for an annual rate of 296 per 100 000 infants. The mean age of intussusception was ∼37 weeks (8.6 months), with 95% of the cases, with only 1% of cases at 1 hospital and 5% at the other hospital requiring surgical intervention. Ultrasound diagnosis was confirmed by an independent radiologist in 94% of a randomly selected group of intussusception cases at 1 of the 2 hospitals. No mortality was reported. Conclusion Vietnam has a substantially higher rate of intussusception in children aged >15 weeks compared with most other regions of the world. Most of our cases were diagnosed by ultrasound, and only a small proportion required surgical intervention with no fatalities, suggesting that the higher rates may be related in part to better and earlier detection of intussusception.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2013.10.006