Inhibition of AGEs formation by natural products

Since advanced glycation end-products (AGEs) inhibitors such as benfotiamine, pyridoxamine and aminoguanidine significantly inhibit the development of retinopathy and neuropathy in streptozotocin-induced diabetic rats, treatment with AGEs inhibitors is believed to be a potential strategy for prevent...

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Bibliographic Details
Published in:Amino acids 2014-02, Vol.46 (2), p.261-266
Main Authors: Nagai, Ryoji, Shirakawa, Jun-ichi, Ohno, Rei-ichi, Moroishi, Narumi, Nagai, Mime
Format: Article
Language:English
Subjects:
advanced glycation end products
Analytical Chemistry
animal disease models
Animals
atherosclerosis
Biochemical Engineering
Biochemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Biomedical and Life Sciences
Carbohydrate Metabolism - drug effects
Diabetes Complications - metabolism
Diabetes Complications - prevention & control
Diabetes Mellitus - drug therapy
Diabetes Mellitus - metabolism
diabetic complications
drugs
Glycation End Products, Advanced - metabolism
Humans
Invited Review
Life Sciences
Lipid Metabolism - drug effects
Lysine - analogs & derivatives
Lysine - metabolism
medicine
Neurobiology
pathogenesis
peripheral nervous system diseases
Proteomics
pyridoxamine
rats
retinal diseases
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Summary:Since advanced glycation end-products (AGEs) inhibitors such as benfotiamine, pyridoxamine and aminoguanidine significantly inhibit the development of retinopathy and neuropathy in streptozotocin-induced diabetic rats, treatment with AGEs inhibitors is believed to be a potential strategy for preventing lifestyle-related diseases such as diabetic complications and atherosclerosis. Furthermore, preventive medicine is the most important approach to preventing lifestyle-related diseases, and improving daily nutritional intake is thought to prevent the pathogenesis of such diseases. Therefore, AGEs inhibitors that can be obtained from daily meals are preferred to prescribed drugs. In this article, we describe a strategy for developing new AGEs inhibitors from natural products.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-013-1487-z