Clinical evaluation of sustained-release metronidazole gel versus metronidazole solution as an intracanal medicament in abscessed primary molars

• Published in: European archives of paediatric dentistry 2014-02, Vol.15 (1), p.19-26
• Main Authors: Bhangdia, M. B., Nandlal, B., Vijaykumar, G. S., Kulkarni, P. K., Shanbhog, R.
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - administration & dosage; Bacteria; Bacterial infections; Bacterial Load - drug effects; Child; Delayed-Action Preparations; Dental Pulp Cavity - drug effects; Dental Pulp Cavity - microbiology; Dental Pulp Necrosis - microbiology; Dental Pulp Necrosis - therapy; Dentistry; Disinfection & disinfectants; Effectiveness; Endodontics; Enterococcus faecalis - drug effects; Gels; Gram-Positive Bacterial Infections - drug therapy; Humans; Infections; Medicine; Metronidazole - administration & dosage; Microorganisms; Molar - microbiology; Original Scientific Article; Periapical Abscess - drug therapy; Periapical Abscess - microbiology; Prevention; Root Canal Irrigants - administration & dosage; Root Canal Preparation - methods; Solutions; Tooth, Deciduous - microbiology; Treatment Outcome; Viscosity
• ISSN: 1818-6300; 1996-9805
• DOI: 10.1007/s40368-013-0047-2

Aim To evaluate the efficacy of metronidazole gel versus metronidazole solution against Enterococcus   faecalis in abscessed primary molars. Study design A clinical trial. Method Twenty pulpally involved non-vital carious human primary mandibular second molars with furcal abscess were randomly allocated into two groups to evaluate the efficacy of metronidazole gel (3 % w/v) and metronidazole solution (0.5 % w/v) against E.   faecalis . Subjects in the first experimental group were subjected to treatment with metronidazole gel (3 % w/v) and subjects in the second experimental group were treated with metronidazole solution (0.5 % w/v). Two microbial samples (pre-operative and post-operative samples) were obtained from the root canals of each subject from both the groups; sub cultured and efficacy of both the groups were evaluated. Results Overall percentage reduction of the mean colony forming unit (CFU) count of metronidazole gel (3 % w/v) group was 96.39 % and metronidazole solution (0.5 % w/v) was 90.90 %. Results of intergroup t test of the percentage difference of mean CFU counts between both the groups revealed a statistically highly significant difference, i.e. p value—0.008 ( p