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Gene polymorphisms and thyroid function in patients with heart failure
We evaluated nuclear factor kappa B { NFkB , rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme { ACE ; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO 2 ) was evaluated (by Weber...
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Published in: | Endocrine 2014-02, Vol.45 (1), p.46-54 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | We evaluated nuclear factor kappa B {
NFkB
, rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme {
ACE
; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO
2
) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO
2
>20 ml/kg/min, group B 16–20 ml/kg/min, group C 10–16 ml/kg/min, and group D 6–10 ml/kg/min. Patients were also genotyped for
NFkB and ACE genetic
variants. T3 was increased and FT3 was decreased for every raise in Weber’s classification (
p
= 0.007 and
p
= 0.012, respectively).
Del
carriers had elevated FT3 levels compared with
Ins
carriers (
p
= 0.021). Patients with
II
genotype had elevated T4 levels compared with
ID
genotype (
p
= 0.044). Both T4 and FT4 were decreased in
D
allele carriers (
p
= 0.007 and
p
= 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the
NFkB
and
ACE
gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF. |
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ISSN: | 1355-008X 1559-0100 |
DOI: | 10.1007/s12020-013-9926-x |