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Gene polymorphisms and thyroid function in patients with heart failure
We evaluated nuclear factor kappa B { NFkB , rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme { ACE ; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO 2 ) was evaluated (by Weber...
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| Published in: | Endocrine 2014-02, Vol.45 (1), p.46-54 |
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| container_end_page | 54 |
| container_issue | 1 |
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| container_title | Endocrine |
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| creator | Vasiliadis, Ioannis Kolovou, Genovefa Kolovou, Vana Giannakopoulou, Vasiliki Boutsikou, Maria Katsiki, Niki Papadopoulou, Evaggelia Mavrogeni, Sophie Sorontila, Konstantina Pantos, Costas Cokkinos, Dennis V. |
| description | We evaluated nuclear factor kappa B {
NFkB
, rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme {
ACE
; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO
2
) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO
2
>20 ml/kg/min, group B 16–20 ml/kg/min, group C 10–16 ml/kg/min, and group D 6–10 ml/kg/min. Patients were also genotyped for
NFkB and ACE genetic
variants. T3 was increased and FT3 was decreased for every raise in Weber’s classification (
p
= 0.007 and
p
= 0.012, respectively).
Del
carriers had elevated FT3 levels compared with
Ins
carriers (
p
= 0.021). Patients with
II
genotype had elevated T4 levels compared with
ID
genotype (
p
= 0.044). Both T4 and FT4 were decreased in
D
allele carriers (
p
= 0.007 and
p
= 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the
NFkB
and
ACE
gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF. |
| doi_str_mv | 10.1007/s12020-013-9926-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1493801536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1493801536</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-71e0357d468304449ff8f5526b71313300c30cfc1e5a74b4fa75f9f898202e513</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhC0EoqXwA7ggH7kE1q88jqiiBQmJC0jcLDexiavECXYi2n-PqxSOnHa1OzPSfAhdE7gjANl9IBQoJEBYUhQ0TXYnaE6EKOIF4DTuTIgEIP-YoYsQtgCU0jQ7RzPKBGecsTlarbXTuO-afdv5vrahDVi5Cg_13ne2wmZ05WA7h63DvRqsdkPA33aoca2VH7BRthm9vkRnRjVBXx3nAr2vHt-WT8nL6_p5-fCSlIzzIcmIBiayiqc5A855YUxuhKDpJiOMMAZQMihNSbRQGd9wozJhCpMXeSyqBWELdDvl9r77GnUYZGtDqZtGOd2NQRJesByIYGmUkkla-i4Er43svW2V30sC8oBPTvhkxCcP-OQuem6O8eOm1dWf45dXFNBJEOLLfWovt93oXaz8T-oPN5R6Wg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1493801536</pqid></control><display><type>article</type><title>Gene polymorphisms and thyroid function in patients with heart failure</title><source>Springer Link</source><creator>Vasiliadis, Ioannis ; Kolovou, Genovefa ; Kolovou, Vana ; Giannakopoulou, Vasiliki ; Boutsikou, Maria ; Katsiki, Niki ; Papadopoulou, Evaggelia ; Mavrogeni, Sophie ; Sorontila, Konstantina ; Pantos, Costas ; Cokkinos, Dennis V.</creator><creatorcontrib>Vasiliadis, Ioannis ; Kolovou, Genovefa ; Kolovou, Vana ; Giannakopoulou, Vasiliki ; Boutsikou, Maria ; Katsiki, Niki ; Papadopoulou, Evaggelia ; Mavrogeni, Sophie ; Sorontila, Konstantina ; Pantos, Costas ; Cokkinos, Dennis V.</creatorcontrib><description>We evaluated nuclear factor kappa B {
NFkB
, rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme {
ACE
; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO
2
) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO
2
>20 ml/kg/min, group B 16–20 ml/kg/min, group C 10–16 ml/kg/min, and group D 6–10 ml/kg/min. Patients were also genotyped for
NFkB and ACE genetic
variants. T3 was increased and FT3 was decreased for every raise in Weber’s classification (
p
= 0.007 and
p
= 0.012, respectively).
Del
carriers had elevated FT3 levels compared with
Ins
carriers (
p
= 0.021). Patients with
II
genotype had elevated T4 levels compared with
ID
genotype (
p
= 0.044). Both T4 and FT4 were decreased in
D
allele carriers (
p
= 0.007 and
p
= 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the
NFkB
and
ACE
gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-013-9926-x</identifier><identifier>PMID: 23543433</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Aged ; Cohort Studies ; Diabetes ; Endocrinology ; Female ; Genotype ; Heart Failure - blood ; Heart Failure - genetics ; Heart Failure - physiopathology ; Humanities and Social Sciences ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; multidisciplinary ; NF-kappa B p50 Subunit - genetics ; Original Article ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic ; Science ; Thyroid Function Tests ; Thyroid Gland - physiology ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Endocrine, 2014-02, Vol.45 (1), p.46-54</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-71e0357d468304449ff8f5526b71313300c30cfc1e5a74b4fa75f9f898202e513</citedby><cites>FETCH-LOGICAL-c344t-71e0357d468304449ff8f5526b71313300c30cfc1e5a74b4fa75f9f898202e513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23543433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasiliadis, Ioannis</creatorcontrib><creatorcontrib>Kolovou, Genovefa</creatorcontrib><creatorcontrib>Kolovou, Vana</creatorcontrib><creatorcontrib>Giannakopoulou, Vasiliki</creatorcontrib><creatorcontrib>Boutsikou, Maria</creatorcontrib><creatorcontrib>Katsiki, Niki</creatorcontrib><creatorcontrib>Papadopoulou, Evaggelia</creatorcontrib><creatorcontrib>Mavrogeni, Sophie</creatorcontrib><creatorcontrib>Sorontila, Konstantina</creatorcontrib><creatorcontrib>Pantos, Costas</creatorcontrib><creatorcontrib>Cokkinos, Dennis V.</creatorcontrib><title>Gene polymorphisms and thyroid function in patients with heart failure</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>We evaluated nuclear factor kappa B {
NFkB
, rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme {
ACE
; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO
2
) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO
2
>20 ml/kg/min, group B 16–20 ml/kg/min, group C 10–16 ml/kg/min, and group D 6–10 ml/kg/min. Patients were also genotyped for
NFkB and ACE genetic
variants. T3 was increased and FT3 was decreased for every raise in Weber’s classification (
p
= 0.007 and
p
= 0.012, respectively).
Del
carriers had elevated FT3 levels compared with
Ins
carriers (
p
= 0.021). Patients with
II
genotype had elevated T4 levels compared with
ID
genotype (
p
= 0.044). Both T4 and FT4 were decreased in
D
allele carriers (
p
= 0.007 and
p
= 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the
NFkB
and
ACE
gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF.</description><subject>Aged</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Genotype</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - genetics</subject><subject>Heart Failure - physiopathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>NF-kappa B p50 Subunit - genetics</subject><subject>Original Article</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Science</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - physiology</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EoqXwA7ggH7kE1q88jqiiBQmJC0jcLDexiavECXYi2n-PqxSOnHa1OzPSfAhdE7gjANl9IBQoJEBYUhQ0TXYnaE6EKOIF4DTuTIgEIP-YoYsQtgCU0jQ7RzPKBGecsTlarbXTuO-afdv5vrahDVi5Cg_13ne2wmZ05WA7h63DvRqsdkPA33aoca2VH7BRthm9vkRnRjVBXx3nAr2vHt-WT8nL6_p5-fCSlIzzIcmIBiayiqc5A855YUxuhKDpJiOMMAZQMihNSbRQGd9wozJhCpMXeSyqBWELdDvl9r77GnUYZGtDqZtGOd2NQRJesByIYGmUkkla-i4Er43svW2V30sC8oBPTvhkxCcP-OQuem6O8eOm1dWf45dXFNBJEOLLfWovt93oXaz8T-oPN5R6Wg</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Vasiliadis, Ioannis</creator><creator>Kolovou, Genovefa</creator><creator>Kolovou, Vana</creator><creator>Giannakopoulou, Vasiliki</creator><creator>Boutsikou, Maria</creator><creator>Katsiki, Niki</creator><creator>Papadopoulou, Evaggelia</creator><creator>Mavrogeni, Sophie</creator><creator>Sorontila, Konstantina</creator><creator>Pantos, Costas</creator><creator>Cokkinos, Dennis V.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Gene polymorphisms and thyroid function in patients with heart failure</title><author>Vasiliadis, Ioannis ; Kolovou, Genovefa ; Kolovou, Vana ; Giannakopoulou, Vasiliki ; Boutsikou, Maria ; Katsiki, Niki ; Papadopoulou, Evaggelia ; Mavrogeni, Sophie ; Sorontila, Konstantina ; Pantos, Costas ; Cokkinos, Dennis V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-71e0357d468304449ff8f5526b71313300c30cfc1e5a74b4fa75f9f898202e513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Genotype</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - genetics</topic><topic>Heart Failure - physiopathology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>NF-kappa B p50 Subunit - genetics</topic><topic>Original Article</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Science</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - physiology</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasiliadis, Ioannis</creatorcontrib><creatorcontrib>Kolovou, Genovefa</creatorcontrib><creatorcontrib>Kolovou, Vana</creatorcontrib><creatorcontrib>Giannakopoulou, Vasiliki</creatorcontrib><creatorcontrib>Boutsikou, Maria</creatorcontrib><creatorcontrib>Katsiki, Niki</creatorcontrib><creatorcontrib>Papadopoulou, Evaggelia</creatorcontrib><creatorcontrib>Mavrogeni, Sophie</creatorcontrib><creatorcontrib>Sorontila, Konstantina</creatorcontrib><creatorcontrib>Pantos, Costas</creatorcontrib><creatorcontrib>Cokkinos, Dennis V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasiliadis, Ioannis</au><au>Kolovou, Genovefa</au><au>Kolovou, Vana</au><au>Giannakopoulou, Vasiliki</au><au>Boutsikou, Maria</au><au>Katsiki, Niki</au><au>Papadopoulou, Evaggelia</au><au>Mavrogeni, Sophie</au><au>Sorontila, Konstantina</au><au>Pantos, Costas</au><au>Cokkinos, Dennis V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene polymorphisms and thyroid function in patients with heart failure</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>45</volume><issue>1</issue><spage>46</spage><epage>54</epage><pages>46-54</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>We evaluated nuclear factor kappa B {
NFkB
, rs28362491 [−94ins/delATTG (W/D)]} and angiotensin converting enzyme {
ACE
; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO
2
) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO
2
>20 ml/kg/min, group B 16–20 ml/kg/min, group C 10–16 ml/kg/min, and group D 6–10 ml/kg/min. Patients were also genotyped for
NFkB and ACE genetic
variants. T3 was increased and FT3 was decreased for every raise in Weber’s classification (
p
= 0.007 and
p
= 0.012, respectively).
Del
carriers had elevated FT3 levels compared with
Ins
carriers (
p
= 0.021). Patients with
II
genotype had elevated T4 levels compared with
ID
genotype (
p
= 0.044). Both T4 and FT4 were decreased in
D
allele carriers (
p
= 0.007 and
p
= 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the
NFkB
and
ACE
gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23543433</pmid><doi>10.1007/s12020-013-9926-x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Endocrine, 2014-02, Vol.45 (1), p.46-54 |
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| language | eng |
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| subjects | Aged Cohort Studies Diabetes Endocrinology Female Genotype Heart Failure - blood Heart Failure - genetics Heart Failure - physiopathology Humanities and Social Sciences Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged multidisciplinary NF-kappa B p50 Subunit - genetics Original Article Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Science Thyroid Function Tests Thyroid Gland - physiology Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood |
| title | Gene polymorphisms and thyroid function in patients with heart failure |
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