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Divalent cations regulate glucagon binding. Evidence for actions on receptor-N sub(s) complexes and on receptors uncoupled from N sub(s)

The effects of Mg super(2+) or ethylenediamine-tetraacetic acid (EDTA) on super(125)I-glucagon binding to rat liver plasma membranes have been characterized. Addition of EDTA or Mg super(2+) diminishes binding in a dose-dependent manner. Divalent cations also affect the sensitivity of hormone-recept...

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Bibliographic Details
Published in:Biochemistry (Easton) 1988-01, Vol.27 (4), p.1111-1116
Main Authors: Lipson, KE, Kolhatkar, AA, Maki, R G, Donner, D B
Format: Article
Language:English
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Summary:The effects of Mg super(2+) or ethylenediamine-tetraacetic acid (EDTA) on super(125)I-glucagon binding to rat liver plasma membranes have been characterized. Addition of EDTA or Mg super(2+) diminishes binding in a dose-dependent manner. Divalent cations also affect the sensitivity of hormone-receptor-regulatory protein complexes to GTP-induced disaggregation.
ISSN:0006-2960