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Divalent cations regulate glucagon binding. Evidence for actions on receptor-N sub(s) complexes and on receptors uncoupled from N sub(s)
The effects of Mg super(2+) or ethylenediamine-tetraacetic acid (EDTA) on super(125)I-glucagon binding to rat liver plasma membranes have been characterized. Addition of EDTA or Mg super(2+) diminishes binding in a dose-dependent manner. Divalent cations also affect the sensitivity of hormone-recept...
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Published in: | Biochemistry (Easton) 1988-01, Vol.27 (4), p.1111-1116 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The effects of Mg super(2+) or ethylenediamine-tetraacetic acid (EDTA) on super(125)I-glucagon binding to rat liver plasma membranes have been characterized. Addition of EDTA or Mg super(2+) diminishes binding in a dose-dependent manner. Divalent cations also affect the sensitivity of hormone-receptor-regulatory protein complexes to GTP-induced disaggregation. |
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ISSN: | 0006-2960 |