A characterization of white matter pathology following spinal cord compression injury in the rat

Highlights • The first characterization of axonal pathology in a rat static compression spinal injury. • Loss of axonal proteins at the lesion epicenter occurs within 1 day of injury. • At 6 weeks, myelination by oligodendrocytes and Schwann cells follows early myelin loss. • The injury spreads both...

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Bibliographic Details
Published in:Neuroscience 2014-02, Vol.260, p.227-239
Main Authors: Ward, R.E, Huang, W, Kostusiak, M, Pallier, P.N, Michael-Titus, A.T, Priestley, J.V
Format: Article
Language:English
Subjects:
Animals
axons
Biological and medical sciences
compression injury
demyelination
Female
Fundamental and applied biological sciences. Psychology
Nerve Fibers, Myelinated - ultrastructure
neurofilament
Neurofilament Proteins - metabolism
Neurology
Neurons - metabolism
Neurons - ultrastructure
Rats
Rats, Sprague-Dawley
Spinal Cord Compression - pathology
spinal cord injury
Thoracic Vertebrae
Vertebrates: nervous system and sense organs
white matter
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Summary:Highlights • The first characterization of axonal pathology in a rat static compression spinal injury. • Loss of axonal proteins at the lesion epicenter occurs within 1 day of injury. • At 6 weeks, myelination by oligodendrocytes and Schwann cells follows early myelin loss. • The injury spreads both rostral and caudal to the epicenter.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.12.024