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A characterization of white matter pathology following spinal cord compression injury in the rat

Highlights • The first characterization of axonal pathology in a rat static compression spinal injury. • Loss of axonal proteins at the lesion epicenter occurs within 1 day of injury. • At 6 weeks, myelination by oligodendrocytes and Schwann cells follows early myelin loss. • The injury spreads both...

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Published in:	Neuroscience 2014-02, Vol.260, p.227-239
Main Authors:	Ward, R.E, Huang, W, Kostusiak, M, Pallier, P.N, Michael-Titus, A.T, Priestley, J.V
Format:	Article
Language:	English
Subjects:	Animals axons Biological and medical sciences compression injury demyelination Female Fundamental and applied biological sciences. Psychology Nerve Fibers, Myelinated - ultrastructure neurofilament Neurofilament Proteins - metabolism Neurology Neurons - metabolism Neurons - ultrastructure Rats Rats, Sprague-Dawley Spinal Cord Compression - pathology spinal cord injury Thoracic Vertebrae Vertebrates: nervous system and sense organs white matter
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creator	Ward, R.E Huang, W Kostusiak, M Pallier, P.N Michael-Titus, A.T Priestley, J.V
description	Highlights • The first characterization of axonal pathology in a rat static compression spinal injury. • Loss of axonal proteins at the lesion epicenter occurs within 1 day of injury. • At 6 weeks, myelination by oligodendrocytes and Schwann cells follows early myelin loss. • The injury spreads both rostral and caudal to the epicenter.
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subjects	Animals axons Biological and medical sciences compression injury demyelination Female Fundamental and applied biological sciences. Psychology Nerve Fibers, Myelinated - ultrastructure neurofilament Neurofilament Proteins - metabolism Neurology Neurons - metabolism Neurons - ultrastructure Rats Rats, Sprague-Dawley Spinal Cord Compression - pathology spinal cord injury Thoracic Vertebrae Vertebrates: nervous system and sense organs white matter
title	A characterization of white matter pathology following spinal cord compression injury in the rat
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