Dopaminergic basis of salience dysregulation in psychosis

Highlights • Psychosis is typified by reality distortion and subcortical dopamine dysfunction. • The two may be linked through aberrant salience processing. • We review evidence for links between dopamine, salience, and psychosis. • We highlight the critical questions that remain and point to future...

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Published in:Trends in neurosciences (Regular ed.) 2014-02, Vol.37 (2), p.85-94
Main Authors: Winton-Brown, Toby T, Fusar-Poli, Paolo, Ungless, Mark A, Howes, Oliver D
Format: Article
Language:English
Subjects:
Dopamine
Dopaminergic Neurons - physiology
Humans
Neurochemistry
Neurology
Neurons
NMR
Nuclear magnetic resonance
Psychosis
Psychotic Disorders - metabolism
Psychotic Disorders - physiopathology
reward
salience
schizophrenia
Schizophrenic Psychology
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description Highlights • Psychosis is typified by reality distortion and subcortical dopamine dysfunction. • The two may be linked through aberrant salience processing. • We review evidence for links between dopamine, salience, and psychosis. • We highlight the critical questions that remain and point to future directions.
doi_str_mv 10.1016/j.tins.2013.11.003
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subjects Dopamine
Dopaminergic Neurons - physiology
Humans
Neurochemistry
Neurology
Neurons
NMR
Nuclear magnetic resonance
Psychosis
Psychotic Disorders - metabolism
Psychotic Disorders - physiopathology
reward
salience
schizophrenia
Schizophrenic Psychology
title Dopaminergic basis of salience dysregulation in psychosis
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