Planting the seed: target recognition of short guide RNAs

Highlights • Seed sequences are present in small RNA-guided gene regulatory and immune systems. • The seed enables a rapid target search by RNA-guided complexes. • Proteins such as Argonaute, Cascade, and Cas9 are essential for seed functioning. • Seed sequences contribute to the evolution of comple...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2014-02, Vol.22 (2), p.74-83
Main Authors: Künne, Tim, Swarts, Daan C, Brouns, Stan J.J
Format: Article
Language:English
Subjects:
Argonaute
Base Pairing
Cas9
Cascade
CRISPR
DNA - genetics
DNA - metabolism
Hfq
Internal Medicine
Models, Biological
RNA, Guide - genetics
RNA, Guide - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNAi
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Summary:Highlights • Seed sequences are present in small RNA-guided gene regulatory and immune systems. • The seed enables a rapid target search by RNA-guided complexes. • Proteins such as Argonaute, Cascade, and Cas9 are essential for seed functioning. • Seed sequences contribute to the evolution of complex gene regulatory networks.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2013.12.003