Phosphotungstic Acid Catalysed One-Pot Synthesis of 5-Alkoxycarbonyl-4-Aryl-3,4-Dihydropyrimidin-2-Ones

5-Alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2-ones are synthesised by the one-pot reactions of aldehydes, ?-ketoesters and urea using a catalytic amount of phosphotungstic acid (PTA) in ethanol. The modified Biginelli cyclocondensation not only shortens the reaction period and simplifies the operat...

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Bibliographic Details
Published in:Journal of chemical research 2004-03, Vol.2004 (3), p.190-191
Main Authors: Jin, Tong-Shou, Xiao, Jin-Chong, Chen, Yan-Xue, Li, Tong-Shuang
Format: Article
Language:English
Subjects:
Aldehydes
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Summary:5-Alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2-ones are synthesised by the one-pot reactions of aldehydes, ?-ketoesters and urea using a catalytic amount of phosphotungstic acid (PTA) in ethanol. The modified Biginelli cyclocondensation not only shortens the reaction period and simplifies the operation, but also improves the yields.
ISSN:1747-5198
2047-6507
DOI:10.3184/0308234041640799