Alkylboronic Esters from Palladium- and Nickel-Catalyzed Borylation of Primary and Secondary Alkyl Bromides

Palladium‐ and nickel‐catalyzed cross‐coupling recations of unactivated alkyl bromides with diboron reagents have been developed as practical methods for the synthesis of primary and secondary alkylboronic esters. These reactions extend the concept and utility of Pd‐ and Ni‐catalyzed cross‐coupling...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2012-06, Vol.354 (9), p.1685-1691
Main Authors: Yi, Jun, Liu, Jin-Hui, Liang, Jun, Dai, Jian-Jun, Yang, Chu-Ting, Fu, Yao, Liu, Lei
Format: Article
Language:English
Subjects:
Aliphatic compounds
alkyl halides
B derivatives
Chemistry
cross-coupling
Exact sciences and technology
nickel
Organic chemistry
organoboron compounds
Organometalloidal and organometallic compounds
palladium
Preparations and properties
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Summary:Palladium‐ and nickel‐catalyzed cross‐coupling recations of unactivated alkyl bromides with diboron reagents have been developed as practical methods for the synthesis of primary and secondary alkylboronic esters. These reactions extend the concept and utility of Pd‐ and Ni‐catalyzed cross‐coupling of aliphatic electrophiles. They also show different substrate selectivity and ligand dependence as compared to the recently reported Cu‐catalyzed borylation reaction.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200136