Aluminum Triflate as a Powerful Catalyst for Direct Amination of Alcohols, Including Electron-Withdrawing Group-Substituted Benzhydrols

Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron‐withdrawing (F, Br, I, NO2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf)3] to afford the corresponding biarylamines in high yield, and the dibromo‐substituted product was further t...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2012-09, Vol.354 (13), p.2447-2452
Main Authors: Ohshima, Takashi, Ipposhi, Junji, Nakahara, Yasuhito, Shibuya, Ryozo, Mashima, Kazushi
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
Aluminum
amination
benzhydrols
Catalysis
Catalysts: preparations and properties
Chemistry
direct substitution
Exact sciences and technology
General and physical chemistry
letrozole
Nitrogen dioxide
Substitutes
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron‐withdrawing (F, Br, I, NO2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf)3] to afford the corresponding biarylamines in high yield, and the dibromo‐substituted product was further transformed into letrozole.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200536