High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells

Gold nanoparticles are efficiently labelled with a luminescent ruthenium complex, producing 13 and 100 nm diameter, monodisperse red-emissive imaging probes with luminescence lifetimes prolonged over the molecular unit. Single, 100 nm particles are observed in whole cell luminescence imaging which r...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (5), p.617-619
Main Authors: Rogers, Nicola J, Claire, Sunil, Harris, Robert M, Farabi, Shiva, Zikeli, Gerald, Styles, Iain B, Hodges, Nikolas J, Pikramenou, Zoe
Format: Article
Language:English
Subjects:
Cancer
Cell Line, Tumor
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - metabolism
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
Microscopy, Confocal
Particle Size
Ruthenium - chemistry
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Summary:Gold nanoparticles are efficiently labelled with a luminescent ruthenium complex, producing 13 and 100 nm diameter, monodisperse red-emissive imaging probes with luminescence lifetimes prolonged over the molecular unit. Single, 100 nm particles are observed in whole cell luminescence imaging which reveals their biomolecular association with chromatin in the nucleus of cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47606e