Cross-Coupling in Flow using Supported Catalysts: Mild, Clean, Efficient and Sustainable Suzuki-Miyaura Coupling in a Single Pass

A mild, clean, practical, sustainable and high yielding procedure for Suzuki–Miyaura cross‐coupling in a single pass using a silica‐supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in react...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2012-12, Vol.354 (18), p.3456-3460
Main Authors: de M. Muñoz, Juan, Alcázar, Jesús, de la Hoz, Antonio, Díaz-Ortiz, Angel
Format: Article
Language:English
Subjects:
Catalysis
cross-coupling
CC bond formation
flow chemistry
solid-supported catalyst
Suzuki-Miyaura reaction
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Summary:A mild, clean, practical, sustainable and high yielding procedure for Suzuki–Miyaura cross‐coupling in a single pass using a silica‐supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed. Different halides/pseudo‐halides and organoboron compounds can be used without modifying the standard procedure.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200678