Nanolithography: User-Friendly Universal and Durable Subcellular-Scaled Template for Protein Binding: Application to Single-Cell Patterning (Adv. Funct. Mater. 47/2013)

A subcellular-scaled protein array is fabricated by J.-W. Jang and co-workers using a parallel dip-pen nanolithography (DPN) patterned template. Micro- or nano-arrays of aldehydesilane are patterned on a SiOx substrate by DPN printing. Extracellular matrix (ECM) proteins, such as fibronectin, are th...

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Bibliographic Details
Published in:Advanced functional materials 2013-12, Vol.23 (47), p.5826-5826
Main Authors: Jang, Jae-Won, Collins, John M., Nettikadan, Saju
Format: Article
Language:English
Subjects:
aldehyde-amine reaction
Arrays
cell patterning
dip-pen nanolithography
nanostructures
protein patterning
Online Access:Get full text
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Summary:A subcellular-scaled protein array is fabricated by J.-W. Jang and co-workers using a parallel dip-pen nanolithography (DPN) patterned template. Micro- or nano-arrays of aldehydesilane are patterned on a SiOx substrate by DPN printing. Extracellular matrix (ECM) proteins, such as fibronectin, are then attached onto the aldehydesilane template. Finally, individual cell arrays are also available by anchoring on ECM protein array. Some big advantages of this method are that the aldehyde-silane template can be stored for up to 1 year, and that user-friendly protein and cell patterning are available.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201370251