Novel methods for in situ characterization of individual micro- and nanoscale magnetic particles

New instrumentation is being developed to better understand the in vivo properties of magnetic particles suspended in solution or lodged in tissue. We describe three novel methods with the necessary sensitivity to measure the microscopic magnetic properties of individual magnetic particles and compl...

Full description

Saved in:
Bibliographic Details
Published in:MRS bulletin 2013-11, Vol.38 (11), p.933-937
Main Authors: Moreland, John, Nakashima, Yoshihiro, Alldredge, Jacob W., Zabow, Gary
Format: Article
Language:English
Subjects:
Applied and Technical Physics
Characterization and Evaluation of Materials
Colloids
Energy Materials
Image resolution
Magnetic Nanoparticles
Magnetic properties
Magnetic resonance imaging
Materials Engineering
Materials Science
Medical imaging
Nanotechnology
NMR
Nuclear magnetic resonance
Sensitivity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:New instrumentation is being developed to better understand the in vivo properties of magnetic particles suspended in solution or lodged in tissue. We describe three novel methods with the necessary sensitivity to measure the microscopic magnetic properties of individual magnetic particles and complexes quantitatively. The first method is based on proton nuclear magnetic resonance of a magnetic particle suspended in water in a microcapillary probe; the second method uses high-resolution magnetic resonance imaging of water surrounding a magnetic particle; and the third method is based on AC susceptometry with a magnetic cantilever that combines magnetic particle imaging concepts with probe microscopy. We present the physical basis for the measurements, estimate sensitivity limits, and discuss future impacts on the development of magnetic particles for bioimaging and bioassays.
ISSN:0883-7694
1938-1425
DOI:10.1557/mrs.2013.258