Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release

In this study, porous poly(lactide‐co‐glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water‐in‐oil‐in‐water (...

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Bibliographic Details
Published in:Polymers for advanced technologies 2014-01, Vol.25 (1), p.16-20
Main Authors: Park, SoHyun, Kwag, Dong Sup, Lee, Ung Yeol, Lee, Dong Jin, Oh, Kyung Taek, Youn, Yu Seok, Lee, Eun Seong
Format: Article
Language:English
Subjects:
Applied sciences
Bicarbonates
Biological and medical sciences
chronic obstructive pulmonary disease
drug release kinetics
Exact sciences and technology
Forms of application and semi-finished materials
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
poly(lactide-co-glycolide)
Polymer industry, paints, wood
porous microparticles
Respiratory system
Technology of polymers
tiotropium
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Summary:In this study, porous poly(lactide‐co‐glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water‐in‐oil‐in‐water (W1/O/W2) multi‐emulsion method using PLGA polymer and ammonium bicarbonate (as a porogen). Herein, soluble starch was incorporated in porous PLGA microparticles for long‐term tiotropium release. In vitro drug release studies determined that the rapid release of tiotropium from porous PLGA microparticles was reduced because of the high viscosity of the incorporated starch. Tiotropium release from porous PLGA microparticles continued up to 3 days. Furthermore, the inhaled microparticles showed longer drug residence in in vivo lung epithelium. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.3198