Toxicokinetics of parathion in the rabbit

The plasma kinetics of parathion were studied in rabbits after i.v. administration of a dose of 1.5 mg/kg and oral administration of 3 mg/kg. The time course of parathion plasma levels administered intravenously followed a three-compartment kinetic model statistically, whereas when administration wa...

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Bibliographic Details
Published in:Archives of toxicology 1988, Vol.61 (3), p.196-200
Main Authors: Pena-Egido, M.J, Rivas-Gonzalo, J.C, Marino-Hernandez, E.L
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Injections, Intravenous
kinetics
Male
parathion
Parathion - administration & dosage
Parathion - pharmacokinetics
Rabbits
toxicity
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Summary:The plasma kinetics of parathion were studied in rabbits after i.v. administration of a dose of 1.5 mg/kg and oral administration of 3 mg/kg. The time course of parathion plasma levels administered intravenously followed a three-compartment kinetic model statistically, whereas when administration was oral, the optimum kinetic model proved to be two-compartmental. The process of the absorption of parathion is very fast with a mean value for the absorption constant (ka) of 33 +/- 15.41 h-1. The slow disposition half-lives for i.v. and oral administration had mean values of 5.08 +/- 3.08 and 1.08 +/- 0.27 h, respectively. From the values established for the parameters defining the distribution process the wide accessibility of parathion to the different body organs and tissues may be seen. Although the compound has a high elimination constant, this process is not limiting to distribution.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00316634