Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan

To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2014-01, Vol.44 (1), p.194-203
Main Authors: Kamio, Yoko, Inada, Naoko, Koyama, Tomonori, Inokuchi, Eiko, Tsuchiya, Kenji, Kuroda, Miho
Format: Article
Language:English
Subjects:
Age
Autism
Autistic spectrum disorders
Behavioral Science and Psychology
Biological and medical sciences
Care and treatment
Check Lists
Checklist
Child and School Psychology
Child clinical studies
Child Development
Child Development Disorders, Pervasive - diagnosis
Child Health
Child, Preschool
Children
Cognitive Development
Developmental Delays
Developmental disorders
Diagnosis
Disability Identification
Female
Foreign Countries
Health
Health aspects
Health Services
Humans
Infant
Infantile autism
Japan
Longitudinal Studies
Male
Mass Screening - methods
Medical sciences
Neurosciences
Original Paper
Pediatrics
Pervasive Developmental Disorders
Psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public Health
Screening
Screening Tests
Sensitivity and Specificity
Toddlers
Young children
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Description
Summary:To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final ASD diagnosis was confirmed at age ≥3 years. Screening identified 20/51 children with ASD: 12/20 true positives were developmentally delayed, whereas 16/22 false negatives were high-functioning. Sensitivity was 0.476, specificity 0.986, positive predictive value 0.455, and likelihood ratio 33.4 for children with ASD. With a few modifications, M-CHAT screening successfully detected toddlers with ASD with and without developmental delay and is a promising screening tool to complement existing community surveillance.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-013-1864-1