METODO, A Prospective Observational Study to Assess the Efficacy and Tolerability of Methadone in Heroin-Addicted Patients Undergoing a Methadone Maintenance Treatment: Preliminary Results at Baseline Evaluation

METODO (methadone efficacy therapy optimization dosage on-going) is a prospective observational study to assess the efficacy and tolerability of methadone in 500 heroin-addicted patients taking a methadone maintenance treatment, enrolled through 2010 to 2011 in five Italian sites, observed over 2 ye...

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Bibliographic Details
Published in:Substance use & misuse 2013-12, Vol.48 (14), p.1530-1540
Main Authors: D'Egidio, Pietro Fausto, Bignamini, Emanuele, De Vivo, Enrico, Leonardi, Claudio, Pieri, Maria Chiara, González-Saiz, Francisco, Lucchini, Alfio
Format: Article
Language:English
Subjects:
Adequacy
Adult
Attrition
Correlation analysis
Dosage
Drug addiction
Drug dosages
Efficacy
Female
Heroin
heroin addiction
Heroin Dependence - drug therapy
Heroin Dependence - rehabilitation
Humans
Male
Methadone
Methadone - adverse effects
Methadone - therapeutic use
methadone dosage adequacy
Methadone Maintenance
methadone maintenance treatment
Middle Aged
Narcotic Antagonists - adverse effects
Narcotic Antagonists - therapeutic use
Observational research
Observational studies
Opiate Dosage Adequacy Scale (ODAS)
Opiate Substitution Treatment - adverse effects
Opiate Substitution Treatment - methods
Opiates
Optimization
Patients
Performance evaluation
Prospective Studies
QT interval
Questionnaires
Retention
Substance abuse treatment
Treatment Outcome
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Summary:METODO (methadone efficacy therapy optimization dosage on-going) is a prospective observational study to assess the efficacy and tolerability of methadone in 500 heroin-addicted patients taking a methadone maintenance treatment, enrolled through 2010 to 2011 in five Italian sites, observed over 2 years. The Opiate Dosage Adequacy Scale has been used for the evaluation of the "adequacy" of the methadone dosage and to stratify patients in adequate and not adequate groups. The treatment efficacy has been evaluated in correlation to the dosage adequacy during the visits. Moreover, patients have been evaluated according to the retention rate and duration of retention in treatment and a series of questionnaires.
ISSN:1082-6084
1532-2491
DOI:10.3109/10826084.2013.800886