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Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension
Aim The role of atenolol, a non‐vasodilating beta‐blocker drug, on long‐term mortality in hypertensive older adults is still unclear. The aim of the present study was to evaluate long‐term mortality in community‐dwelling hypertensive older adults taking atenolol. Methods Long‐term mortality after 12...
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| Published in: | Geriatrics & gerontology international 2014-01, Vol.14 (1), p.153-158 |
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| container_title | Geriatrics & gerontology international |
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| creator | Testa, Gianluca Cacciatore, Francesco Della-Morte, David Mazzella, Francesca Mastrobuoni, Chiara Galizia, Gianluigi Gargiulo, Gaetano Rengo, Franco Bonaduce, Domenico Abete, Pasquale |
| description | Aim
The role of atenolol, a non‐vasodilating beta‐blocker drug, on long‐term mortality in hypertensive older adults is still unclear. The aim of the present study was to evaluate long‐term mortality in community‐dwelling hypertensive older adults taking atenolol.
Methods
Long‐term mortality after 12‐year follow up in isolated hypertensive older adults (n = 972) was analyzed. The patients were stratified in the presence and absence of atenolol use. Systolic, diastolic and pulse arterial pressure were measured.
Results
Older adults taking atenolol showed a greater mortality and higher pulse arterial pressure values than those not taking atenolol (73.9% vs 55.0%; P = 0.047 and 74.7 ± 14.1 vs 63.0 ± 14.2 mmHg, P |
| doi_str_mv | 10.1111/ggi.12073 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1496880955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1490719811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4483-29063d3b9ee4875756266708e9a1fd0fa77ec9df80418981073bcf1cba63df483</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS1ERUthwQsgS2zKIq1v_JtlqcrQUv6kIpaWJ3FmXJx4sB0N8_a4TdsFEhLe2Ja-811bB6FXQI6hrJPVyh1DTSR9gg6AMVkR3rCnd2dWAVdiHz1P6YYQkA3AM7RfU65AMHaA1qfZjsEHj6dksUvYpBRaZ7Lt8NblNfZhXFXZxgEPIWbjXd5hN-I2DMM0lkvVba33blzh4Dsbsekmn9OcXe82NhZ_cmF8gfZ645N9eb8fou_vz6_PPlRXXxYXZ6dXVcuYolXdEEE7umysZUpyyUUthCTKNgb6jvRGSts2Xa8IA9UoKJ9etj20S1NifTEcoqPZu4nh12RT1oNLbXmiGW2YkgbWCKVIw_n_oERCGQIFffMXehOmOJaPFEqKGoDT29lvZ6qNIaVoe72JbjBxp4Ho26Z0aUrfNVXY1_fGaTnY7pF8qKYAJzOwdd7u_m3Si8XFg7KaEy5l-_sxYeJPLSSVXP_4vNBfry_FR_rtk35H_wCvNKwk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1476211538</pqid></control><display><type>article</type><title>Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension</title><source>Wiley</source><creator>Testa, Gianluca ; Cacciatore, Francesco ; Della-Morte, David ; Mazzella, Francesca ; Mastrobuoni, Chiara ; Galizia, Gianluigi ; Gargiulo, Gaetano ; Rengo, Franco ; Bonaduce, Domenico ; Abete, Pasquale</creator><creatorcontrib>Testa, Gianluca ; Cacciatore, Francesco ; Della-Morte, David ; Mazzella, Francesca ; Mastrobuoni, Chiara ; Galizia, Gianluigi ; Gargiulo, Gaetano ; Rengo, Franco ; Bonaduce, Domenico ; Abete, Pasquale</creatorcontrib><description>Aim
The role of atenolol, a non‐vasodilating beta‐blocker drug, on long‐term mortality in hypertensive older adults is still unclear. The aim of the present study was to evaluate long‐term mortality in community‐dwelling hypertensive older adults taking atenolol.
Methods
Long‐term mortality after 12‐year follow up in isolated hypertensive older adults (n = 972) was analyzed. The patients were stratified in the presence and absence of atenolol use. Systolic, diastolic and pulse arterial pressure were measured.
Results
Older adults taking atenolol showed a greater mortality and higher pulse arterial pressure values than those not taking atenolol (73.9% vs 55.0%; P = 0.047 and 74.7 ± 14.1 vs 63.0 ± 14.2 mmHg, P < 0.001, respectively). Cox regression analysis showed that atenolol use (hazard risk 1.91; 95% confidence interval 1.04–4.31; P = 0.04) and pulse arterial pressure (hazard risk 1.02; 95% confidence interval 1.01–1.03; P = 0.032) were predictive of long‐term mortality.
Conclusions
Atenolol use was related to increased mortality in community‐dwelling hypertensive Older adults. This increase in mortality risk seems to be related to an increase of pulse arterial pressure. Geriatr Gerontol Int 2014; 14: 153–158.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.12073</identifier><identifier>PMID: 23581644</identifier><language>eng</language><publisher>Japan: Blackwell Publishing Ltd</publisher><subject>Adrenergic beta-1 Receptor Antagonists - administration & dosage ; Adrenergic beta-1 Receptor Antagonists - adverse effects ; Aged ; Arterial Pressure - drug effects ; Arterial Pressure - physiology ; atenolol ; Atenolol - administration & dosage ; Atenolol - adverse effects ; Beta blockers ; Confidence Intervals ; Cross-Sectional Studies ; Dose-Response Relationship, Drug ; Drugs ; elderly ; Female ; Follow-Up Studies ; Forecasting ; Geriatric Assessment - methods ; Geriatrics ; Humans ; Hypertension ; Hypertension - drug therapy ; Hypertension - mortality ; Hypertension - physiopathology ; Italy - epidemiology ; long-term mortality ; Male ; Middle Aged ; Mortality ; Proportional Hazards Models ; pulse arterial pressure ; Retrospective Studies ; Risk Factors ; Studies ; Survival Rate - trends</subject><ispartof>Geriatrics & gerontology international, 2014-01, Vol.14 (1), p.153-158</ispartof><rights>2013 Japan Geriatrics Society</rights><rights>2013 Japan Geriatrics Society.</rights><rights>Copyright © 2014 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4483-29063d3b9ee4875756266708e9a1fd0fa77ec9df80418981073bcf1cba63df483</citedby><cites>FETCH-LOGICAL-c4483-29063d3b9ee4875756266708e9a1fd0fa77ec9df80418981073bcf1cba63df483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23581644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Testa, Gianluca</creatorcontrib><creatorcontrib>Cacciatore, Francesco</creatorcontrib><creatorcontrib>Della-Morte, David</creatorcontrib><creatorcontrib>Mazzella, Francesca</creatorcontrib><creatorcontrib>Mastrobuoni, Chiara</creatorcontrib><creatorcontrib>Galizia, Gianluigi</creatorcontrib><creatorcontrib>Gargiulo, Gaetano</creatorcontrib><creatorcontrib>Rengo, Franco</creatorcontrib><creatorcontrib>Bonaduce, Domenico</creatorcontrib><creatorcontrib>Abete, Pasquale</creatorcontrib><title>Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension</title><title>Geriatrics & gerontology international</title><addtitle>Geriatrics & Gerontology International</addtitle><description>Aim
The role of atenolol, a non‐vasodilating beta‐blocker drug, on long‐term mortality in hypertensive older adults is still unclear. The aim of the present study was to evaluate long‐term mortality in community‐dwelling hypertensive older adults taking atenolol.
Methods
Long‐term mortality after 12‐year follow up in isolated hypertensive older adults (n = 972) was analyzed. The patients were stratified in the presence and absence of atenolol use. Systolic, diastolic and pulse arterial pressure were measured.
Results
Older adults taking atenolol showed a greater mortality and higher pulse arterial pressure values than those not taking atenolol (73.9% vs 55.0%; P = 0.047 and 74.7 ± 14.1 vs 63.0 ± 14.2 mmHg, P < 0.001, respectively). Cox regression analysis showed that atenolol use (hazard risk 1.91; 95% confidence interval 1.04–4.31; P = 0.04) and pulse arterial pressure (hazard risk 1.02; 95% confidence interval 1.01–1.03; P = 0.032) were predictive of long‐term mortality.
Conclusions
Atenolol use was related to increased mortality in community‐dwelling hypertensive Older adults. This increase in mortality risk seems to be related to an increase of pulse arterial pressure. Geriatr Gerontol Int 2014; 14: 153–158.</description><subject>Adrenergic beta-1 Receptor Antagonists - administration & dosage</subject><subject>Adrenergic beta-1 Receptor Antagonists - adverse effects</subject><subject>Aged</subject><subject>Arterial Pressure - drug effects</subject><subject>Arterial Pressure - physiology</subject><subject>atenolol</subject><subject>Atenolol - administration & dosage</subject><subject>Atenolol - adverse effects</subject><subject>Beta blockers</subject><subject>Confidence Intervals</subject><subject>Cross-Sectional Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs</subject><subject>elderly</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forecasting</subject><subject>Geriatric Assessment - methods</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - mortality</subject><subject>Hypertension - physiopathology</subject><subject>Italy - epidemiology</subject><subject>long-term mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Proportional Hazards Models</subject><subject>pulse arterial pressure</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Survival Rate - trends</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS1ERUthwQsgS2zKIq1v_JtlqcrQUv6kIpaWJ3FmXJx4sB0N8_a4TdsFEhLe2Ja-811bB6FXQI6hrJPVyh1DTSR9gg6AMVkR3rCnd2dWAVdiHz1P6YYQkA3AM7RfU65AMHaA1qfZjsEHj6dksUvYpBRaZ7Lt8NblNfZhXFXZxgEPIWbjXd5hN-I2DMM0lkvVba33blzh4Dsbsekmn9OcXe82NhZ_cmF8gfZ645N9eb8fou_vz6_PPlRXXxYXZ6dXVcuYolXdEEE7umysZUpyyUUthCTKNgb6jvRGSts2Xa8IA9UoKJ9etj20S1NifTEcoqPZu4nh12RT1oNLbXmiGW2YkgbWCKVIw_n_oERCGQIFffMXehOmOJaPFEqKGoDT29lvZ6qNIaVoe72JbjBxp4Ho26Z0aUrfNVXY1_fGaTnY7pF8qKYAJzOwdd7u_m3Si8XFg7KaEy5l-_sxYeJPLSSVXP_4vNBfry_FR_rtk35H_wCvNKwk</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Testa, Gianluca</creator><creator>Cacciatore, Francesco</creator><creator>Della-Morte, David</creator><creator>Mazzella, Francesca</creator><creator>Mastrobuoni, Chiara</creator><creator>Galizia, Gianluigi</creator><creator>Gargiulo, Gaetano</creator><creator>Rengo, Franco</creator><creator>Bonaduce, Domenico</creator><creator>Abete, Pasquale</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201401</creationdate><title>Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension</title><author>Testa, Gianluca ; Cacciatore, Francesco ; Della-Morte, David ; Mazzella, Francesca ; Mastrobuoni, Chiara ; Galizia, Gianluigi ; Gargiulo, Gaetano ; Rengo, Franco ; Bonaduce, Domenico ; Abete, Pasquale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4483-29063d3b9ee4875756266708e9a1fd0fa77ec9df80418981073bcf1cba63df483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adrenergic beta-1 Receptor Antagonists - administration & dosage</topic><topic>Adrenergic beta-1 Receptor Antagonists - adverse effects</topic><topic>Aged</topic><topic>Arterial Pressure - drug effects</topic><topic>Arterial Pressure - physiology</topic><topic>atenolol</topic><topic>Atenolol - administration & dosage</topic><topic>Atenolol - adverse effects</topic><topic>Beta blockers</topic><topic>Confidence Intervals</topic><topic>Cross-Sectional Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs</topic><topic>elderly</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forecasting</topic><topic>Geriatric Assessment - methods</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - mortality</topic><topic>Hypertension - physiopathology</topic><topic>Italy - epidemiology</topic><topic>long-term mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Proportional Hazards Models</topic><topic>pulse arterial pressure</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Survival Rate - trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Testa, Gianluca</creatorcontrib><creatorcontrib>Cacciatore, Francesco</creatorcontrib><creatorcontrib>Della-Morte, David</creatorcontrib><creatorcontrib>Mazzella, Francesca</creatorcontrib><creatorcontrib>Mastrobuoni, Chiara</creatorcontrib><creatorcontrib>Galizia, Gianluigi</creatorcontrib><creatorcontrib>Gargiulo, Gaetano</creatorcontrib><creatorcontrib>Rengo, Franco</creatorcontrib><creatorcontrib>Bonaduce, Domenico</creatorcontrib><creatorcontrib>Abete, Pasquale</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Testa, Gianluca</au><au>Cacciatore, Francesco</au><au>Della-Morte, David</au><au>Mazzella, Francesca</au><au>Mastrobuoni, Chiara</au><au>Galizia, Gianluigi</au><au>Gargiulo, Gaetano</au><au>Rengo, Franco</au><au>Bonaduce, Domenico</au><au>Abete, Pasquale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension</atitle><jtitle>Geriatrics & gerontology international</jtitle><addtitle>Geriatrics & Gerontology International</addtitle><date>2014-01</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>153</spage><epage>158</epage><pages>153-158</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim
The role of atenolol, a non‐vasodilating beta‐blocker drug, on long‐term mortality in hypertensive older adults is still unclear. The aim of the present study was to evaluate long‐term mortality in community‐dwelling hypertensive older adults taking atenolol.
Methods
Long‐term mortality after 12‐year follow up in isolated hypertensive older adults (n = 972) was analyzed. The patients were stratified in the presence and absence of atenolol use. Systolic, diastolic and pulse arterial pressure were measured.
Results
Older adults taking atenolol showed a greater mortality and higher pulse arterial pressure values than those not taking atenolol (73.9% vs 55.0%; P = 0.047 and 74.7 ± 14.1 vs 63.0 ± 14.2 mmHg, P < 0.001, respectively). Cox regression analysis showed that atenolol use (hazard risk 1.91; 95% confidence interval 1.04–4.31; P = 0.04) and pulse arterial pressure (hazard risk 1.02; 95% confidence interval 1.01–1.03; P = 0.032) were predictive of long‐term mortality.
Conclusions
Atenolol use was related to increased mortality in community‐dwelling hypertensive Older adults. This increase in mortality risk seems to be related to an increase of pulse arterial pressure. Geriatr Gerontol Int 2014; 14: 153–158.</abstract><cop>Japan</cop><pub>Blackwell Publishing Ltd</pub><pmid>23581644</pmid><doi>10.1111/ggi.12073</doi><tpages>6</tpages></addata></record> |
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| source | Wiley |
| subjects | Adrenergic beta-1 Receptor Antagonists - administration & dosage Adrenergic beta-1 Receptor Antagonists - adverse effects Aged Arterial Pressure - drug effects Arterial Pressure - physiology atenolol Atenolol - administration & dosage Atenolol - adverse effects Beta blockers Confidence Intervals Cross-Sectional Studies Dose-Response Relationship, Drug Drugs elderly Female Follow-Up Studies Forecasting Geriatric Assessment - methods Geriatrics Humans Hypertension Hypertension - drug therapy Hypertension - mortality Hypertension - physiopathology Italy - epidemiology long-term mortality Male Middle Aged Mortality Proportional Hazards Models pulse arterial pressure Retrospective Studies Risk Factors Studies Survival Rate - trends |
| title | Atenolol use is associated with long-term mortality in community-dwelling older adults with hypertension |
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