Circulating Lipocalin-2 and Retinol-Binding Protein 4 Are Associated with Intima-Media Thickness and Subclinical Atherosclerosis in Patients with Type 2 Diabetes. e66607

Background The lipocalin family proteins, including lipocalin-2 and retinol-binding protein 4 (RBP4), are adipokines closely associated with obesity-related metabolic disorders. In this study, we evaluated the association of serum lipocalin-2 and RBP4 with intima-media thickness (IMT) and subclinica...

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Published in:PloS one 2013-06, Vol.8 (6)
Main Authors: Xiao, Yang, Xu, Aimin, Hui, Xiaoyan, Zhou, Pengcheng, Li, Xing, Zhong, Hui, Tang, Weili, Huang, Gan, Zhou, Zhiguang
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container_title PloS one
container_volume 8
creator Xiao, Yang
Xu, Aimin
Hui, Xiaoyan
Zhou, Pengcheng
Li, Xing
Zhong, Hui
Tang, Weili
Huang, Gan
Zhou, Zhiguang
description Background The lipocalin family proteins, including lipocalin-2 and retinol-binding protein 4 (RBP4), are adipokines closely associated with obesity-related metabolic disorders. In this study, we evaluated the association of serum lipocalin-2 and RBP4 with intima-media thickness (IMT) and subclinical atherosclerosis in type 2 diabetic patients. Methods and Results Serum levels of lipocalin-2 and RBP4 were measured in 284 type 2 diabetic patients. Subclinical atherosclerosis was assessed by IMT at carotid, femoral and iliac arteries with ultrasound. Patients with subclinical atherosclerosis showed significantly higher circulating concentrations of lipocalin-2 and RBP4 when compared to those without [112.9 (86.4 to 202.1) mu g/L versus 77.2(55.0-150.4) mu g/L, 37.1(32.3-40.8) mg/L versus 23.2(20.1-29.2) mg/L, respectively; P = 0.002, P
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In this study, we evaluated the association of serum lipocalin-2 and RBP4 with intima-media thickness (IMT) and subclinical atherosclerosis in type 2 diabetic patients. Methods and Results Serum levels of lipocalin-2 and RBP4 were measured in 284 type 2 diabetic patients. Subclinical atherosclerosis was assessed by IMT at carotid, femoral and iliac arteries with ultrasound. Patients with subclinical atherosclerosis showed significantly higher circulating concentrations of lipocalin-2 and RBP4 when compared to those without [112.9 (86.4 to 202.1) mu g/L versus 77.2(55.0-150.4) mu g/L, 37.1(32.3-40.8) mg/L versus 23.2(20.1-29.2) mg/L, respectively; P = 0.002, P&lt;0.001, respectively]. Moreover, positive correlations were observed between carotid IMT and lipocalin-2 (r = 0.170, P = 0.018) or RBP4 (r = 0.132, P = 0.040), femoral IMT and lipocalin-2 (r = 0.160, P = 0.027), as well as between iliac IMT and RBP4 (r = 0.241, P&lt;0.001). Multiple logistic regression analysis further demonstrated that these two adipokines were independent risk factors for subclinical atherosclerosis in type 2 diabetes. Conclusion Circulating levels of lipocalin-2 and RBP4 are positively correlated with carotid IMT and subclinical atherosclerosis in type 2 diabetes, which suggests a potential role of these two lipid-binding chaperones in the pathogenesis of vascular complications of diabetes.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0066607</identifier><language>eng</language><ispartof>PloS one, 2013-06, Vol.8 (6)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,37013</link.rule.ids></links><search><creatorcontrib>Xiao, Yang</creatorcontrib><creatorcontrib>Xu, Aimin</creatorcontrib><creatorcontrib>Hui, Xiaoyan</creatorcontrib><creatorcontrib>Zhou, Pengcheng</creatorcontrib><creatorcontrib>Li, Xing</creatorcontrib><creatorcontrib>Zhong, Hui</creatorcontrib><creatorcontrib>Tang, Weili</creatorcontrib><creatorcontrib>Huang, Gan</creatorcontrib><creatorcontrib>Zhou, Zhiguang</creatorcontrib><title>Circulating Lipocalin-2 and Retinol-Binding Protein 4 Are Associated with Intima-Media Thickness and Subclinical Atherosclerosis in Patients with Type 2 Diabetes. e66607</title><title>PloS one</title><description>Background The lipocalin family proteins, including lipocalin-2 and retinol-binding protein 4 (RBP4), are adipokines closely associated with obesity-related metabolic disorders. In this study, we evaluated the association of serum lipocalin-2 and RBP4 with intima-media thickness (IMT) and subclinical atherosclerosis in type 2 diabetic patients. Methods and Results Serum levels of lipocalin-2 and RBP4 were measured in 284 type 2 diabetic patients. Subclinical atherosclerosis was assessed by IMT at carotid, femoral and iliac arteries with ultrasound. Patients with subclinical atherosclerosis showed significantly higher circulating concentrations of lipocalin-2 and RBP4 when compared to those without [112.9 (86.4 to 202.1) mu g/L versus 77.2(55.0-150.4) mu g/L, 37.1(32.3-40.8) mg/L versus 23.2(20.1-29.2) mg/L, respectively; P = 0.002, P&lt;0.001, respectively]. Moreover, positive correlations were observed between carotid IMT and lipocalin-2 (r = 0.170, P = 0.018) or RBP4 (r = 0.132, P = 0.040), femoral IMT and lipocalin-2 (r = 0.160, P = 0.027), as well as between iliac IMT and RBP4 (r = 0.241, P&lt;0.001). Multiple logistic regression analysis further demonstrated that these two adipokines were independent risk factors for subclinical atherosclerosis in type 2 diabetes. Conclusion Circulating levels of lipocalin-2 and RBP4 are positively correlated with carotid IMT and subclinical atherosclerosis in type 2 diabetes, which suggests a potential role of these two lipid-binding chaperones in the pathogenesis of vascular complications of diabetes.</description><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVz81OwzAMB_AICYnx8QYcfOTSkrZb2h3LAA0JpAl6n7LUUI8sKXEqxCPxlnSDF-BiS_5bP8tCXGYyzYoyu976ITht0947TKVUSsnySEyyeZEnKpfFiThl3ko5KyqlJuJ7QcEMVkdyb_BIvTfakkty0K6FZxzH3iY35Np9vgo-IjmYQh0QamZvSEds4ZNiBw8u0k4nT9iShqYj8-6Q-QC9DBszsjTiUMcOg2dj95UYRm81nkcX-ddpvnqEHG5JbzAip4CHJ87F8au2jBd__Uxc3d81i2XSB_8xIMf1jtigtdqhH3idTeeqqrJ8Vhb_WP0BVutpWw</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Xiao, Yang</creator><creator>Xu, Aimin</creator><creator>Hui, Xiaoyan</creator><creator>Zhou, Pengcheng</creator><creator>Li, Xing</creator><creator>Zhong, Hui</creator><creator>Tang, Weili</creator><creator>Huang, Gan</creator><creator>Zhou, Zhiguang</creator><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20130601</creationdate><title>Circulating Lipocalin-2 and Retinol-Binding Protein 4 Are Associated with Intima-Media Thickness and Subclinical Atherosclerosis in Patients with Type 2 Diabetes. e66607</title><author>Xiao, Yang ; Xu, Aimin ; Hui, Xiaoyan ; Zhou, Pengcheng ; Li, Xing ; Zhong, Hui ; Tang, Weili ; Huang, Gan ; Zhou, Zhiguang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_14968812573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Yang</creatorcontrib><creatorcontrib>Xu, Aimin</creatorcontrib><creatorcontrib>Hui, Xiaoyan</creatorcontrib><creatorcontrib>Zhou, Pengcheng</creatorcontrib><creatorcontrib>Li, Xing</creatorcontrib><creatorcontrib>Zhong, Hui</creatorcontrib><creatorcontrib>Tang, Weili</creatorcontrib><creatorcontrib>Huang, Gan</creatorcontrib><creatorcontrib>Zhou, Zhiguang</creatorcontrib><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Yang</au><au>Xu, Aimin</au><au>Hui, Xiaoyan</au><au>Zhou, Pengcheng</au><au>Li, Xing</au><au>Zhong, Hui</au><au>Tang, Weili</au><au>Huang, Gan</au><au>Zhou, Zhiguang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Lipocalin-2 and Retinol-Binding Protein 4 Are Associated with Intima-Media Thickness and Subclinical Atherosclerosis in Patients with Type 2 Diabetes. e66607</atitle><jtitle>PloS one</jtitle><date>2013-06-01</date><risdate>2013</risdate><volume>8</volume><issue>6</issue><eissn>1932-6203</eissn><abstract>Background The lipocalin family proteins, including lipocalin-2 and retinol-binding protein 4 (RBP4), are adipokines closely associated with obesity-related metabolic disorders. In this study, we evaluated the association of serum lipocalin-2 and RBP4 with intima-media thickness (IMT) and subclinical atherosclerosis in type 2 diabetic patients. Methods and Results Serum levels of lipocalin-2 and RBP4 were measured in 284 type 2 diabetic patients. Subclinical atherosclerosis was assessed by IMT at carotid, femoral and iliac arteries with ultrasound. Patients with subclinical atherosclerosis showed significantly higher circulating concentrations of lipocalin-2 and RBP4 when compared to those without [112.9 (86.4 to 202.1) mu g/L versus 77.2(55.0-150.4) mu g/L, 37.1(32.3-40.8) mg/L versus 23.2(20.1-29.2) mg/L, respectively; P = 0.002, P&lt;0.001, respectively]. Moreover, positive correlations were observed between carotid IMT and lipocalin-2 (r = 0.170, P = 0.018) or RBP4 (r = 0.132, P = 0.040), femoral IMT and lipocalin-2 (r = 0.160, P = 0.027), as well as between iliac IMT and RBP4 (r = 0.241, P&lt;0.001). Multiple logistic regression analysis further demonstrated that these two adipokines were independent risk factors for subclinical atherosclerosis in type 2 diabetes. Conclusion Circulating levels of lipocalin-2 and RBP4 are positively correlated with carotid IMT and subclinical atherosclerosis in type 2 diabetes, which suggests a potential role of these two lipid-binding chaperones in the pathogenesis of vascular complications of diabetes.</abstract><doi>10.1371/journal.pone.0066607</doi></addata></record>
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title Circulating Lipocalin-2 and Retinol-Binding Protein 4 Are Associated with Intima-Media Thickness and Subclinical Atherosclerosis in Patients with Type 2 Diabetes. e66607
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