Effects of equid herpesvirus 1 (EHV-1) AR8 and HH1 strains on BALB-c mice

Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detectio...

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Bibliographic Details
Published in:Archives of virology 2014, Vol.159 (1), p.141-145
Main Authors: Zanuzzi, Carolina, Scrochi, Mariela, Fuentealba, Nadia, Nishida, Fabián, Portiansky, Enrique, Muglia, Cecilia, Gimeno, Eduardo, Barbeito, Claudio, Galosi, Cecilia
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Brief Report
Disease Models, Animal
Dyspnea
Herpes viruses
Herpesviridae Infections - pathology
Herpesviridae Infections - veterinary
Herpesviridae Infections - virology
Herpesvirus
Herpesvirus 1, Equid - classification
Herpesvirus 1, Equid - genetics
Herpesvirus 1, Equid - physiology
Horse Diseases - pathology
Horse Diseases - virology
Horses
Infections
Infectious Diseases
Laboratory animals
Leukocytes
Liver
Male
Medical Microbiology
Mice
Mice, Inbred BALB C
Spleen
Variance analysis
Virology
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Summary:Here, we used a murine model to describe and compare the pathogenic potential of the Argentinean equid herpesvirus 1 (EHV-1) AR8 strain with the Japanese HH1 reference strain. In AR8-inoculated animals, clinical signs began earlier, but the viremic phase was shorter. Virus isolation and DNA detection in the lungs, liver and spleen were positive for both strains at different times postinfection (pi). Infection foci produced by both strains were immunohistochemically detected in lungs from day 1 to day 4 pi. We conclude that whichever EHV-1 strain is selected to experimentally reproduce the disease, it needs appropriate standardization in order to provide valid conclusions.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-013-1782-8